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Cat. No.: HY-N2892

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Aristolactam A IIIa

(Synonyms: Aristololactam A IIIa; Sch 546909)

Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells.

For research use only. We do not sell to patients.

CAS No.: 97399-91-2
Formula: C₁₆H₁₁NO₄
Molecular Weight:281.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Aristolactam A IIIa Chemical Structure

CAS No.: 97399-91-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All DYRK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	19.2 μM Compound: 6	Inhibition of LPS-induced BALB/c mouse B cell proliferation Inhibition of LPS-induced BALB/c mouse B cell proliferation	[PMID: 17081761]
MCF7	IC₅₀	>10 nM Compound: SCH-546909	Antiproliferative activity against human MCF7 cells by soft agar growth assay Antiproliferative activity against human MCF7 cells by soft agar growth assay	[PMID: 20097066]
MCF7	IC₅₀	3 μM Compound: SCH-546909	Antiproliferative activity against human MCF7 cells by clonogenicity assay Antiproliferative activity against human MCF7 cells by clonogenicity assay	[PMID: 20097066]
T-cell	IC₅₀	18.5 μM Compound: 6	Inhibition of ConA-induced BALB/c mouse T cell proliferation Inhibition of ConA-induced BALB/c mouse T cell proliferation	[PMID: 17081761]

Chemical Information

CAS No. 97399-91-2
Molecular Weight 281.26
Formula C₁₆H₁₁NO₄
SMILES

O=C1NC2=C3C1=CC(O)=C(OC)C3=C4C(C=CC(O)=C4)=C2
Synonyms

Aristololactam A IIIa; Sch 546909
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chia YC, et al. Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. J Nat Prod. 2000 Aug;63(8):1160-3. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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