2. Others Membrane Transporter/Ion Channel
  3. Drug Derivative P-glycoprotein
  4. 10S,13aR-Antofine N-oxide

10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers.

For research use only. We do not sell to patients.

10S,13aR-Antofine N-oxide

10S,13aR-Antofine N-oxide Chemical Structure

CAS No. : 314744-17-7

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10S,13aR-Antofine N-oxide Related Antibodies

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Description

10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers[1].

In Vitro

10S,13aR-Antofine N-oxide (compound 1) (72 h) potently inhibits the growth of KB-3-1 drug-sensitive carcinoma cells with an IC50 of 0.11 μM, and shows only marginal resistance (less than 2-fold) in KB-V1 multi-drug-resistant carcinoma cells with an IC50 of 0.16 μM, demonstrating it is a poor substrate for the P-glycoprotein efflux pump[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10S,13aR-Antofine N-oxide Related Antibodies
Molecular Weight

379.45

Formula

C23H25NO4
CAS No.
SMILES

[O-][N@@+]12CC3=C(C=CC(OC)=C4)C4=C(C=C(C(OC)=C5)OC)C5=C3C[C@@]1([H])CCC2
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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10S,13aR-Antofine N-oxide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10S,13aR-Antofine N-oxide314744-17-7Drug DerivativeP-glycoproteinDrug derivativeP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243cancer cellsKB-3-1 drug-sensitive carcinoma cellsCynanchum vincetoxicummulti-drug-resistant carcinoma cellsP-glycoprotein (P-170) efflux pumpphenanthroindolizidine N-oxide alkaloidcarcinomaKB-V1 multi-drug-resistant carcinoma cellsInhibitorinhibitorinhibit

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