314744-17-7
Chemical Structure
10S,13aR-Antofine N-oxide
- CAS No.: 314744-17-7
- Formula:C23H25NO4
- Molecular Weight:379.45
InChIKey: MUSNTDDWXDJEFG-SHACYNPGSA-N
SMILES: [O-][N@@+]12CC3=C(C=CC(OC)=C4)C4=C(C=C(C(OC)=C5)OC)C5=C3C[C@@]1([H])CCC2
Biological Activity: 10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers[1].
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10S,13aR-Antofine N-oxide | 10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers. | |||||||||||||||||||||
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