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Cat. No.: HY-N7735

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6-Methoxyspirotryprostatin B

6-Methoxyspirotryprostatin B is a natural alkaloid.

For research use only. We do not sell to patients.

CAS No.: 1031727-28-2
Formula: C₂₂H₂₃N₃O₄
Molecular Weight:393.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

6-Methoxyspirotryprostatin B Chemical Structure

CAS No.: 1031727-28-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

6-Methoxyspirotryprostatin B is a natural alkaloid.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.29 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 18505285]
HL-60	IC₅₀	9.71 μM Compound: 1	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 18505285]
Jurkat	IC₅₀	21.1 μM Compound: 13	Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay	[PMID: 20303767]
K562	IC₅₀	41 μM Compound: 7	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 19256529]

In Vitro

6-Methoxyspirotryprostatin B (1 μM-10 mM; 72 h) weakly inhibits A-549 cell viability (IC₅₀ = 8.29 μM) and slightly inhibits HL-60 cell viability (IC₅₀ = 9.71 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1031727-28-2
Molecular Weight 393.44
Formula C₂₂H₂₃N₃O₄
SMILES

O=C([C@]([C@@H]1/C=C(C)\C)2C=C(N1C3=O)C(N4[C@@]3([H])CCC4)=O)NC5=C2C=CC(OC)=C5
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Aspergillus sydowi
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang M, et al. Cytotoxic alkaloids and antibiotic nordammarane triterpenoids from the marine-derived fungus Aspergillus sydowi. J Nat Prod. 2008;71(6):985-989. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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