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Results for "

α-glucosidase activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (1) Amylases (27) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (4) Apoptosis (10) Aryl Hydrocarbon Receptor (3) Aurora Kinase (1) Bacterial (10) Bcl-2 Family (1) c-Kit (1) Carbonic Anhydrase (2) Cholinesterase (ChE) (5) COX (3) Dengue Virus (1) Dipeptidyl Peptidase (5) DNA/RNA Synthesis (1) Drug Metabolite (1) Endogenous Metabolite (11) Environmental Pollutants (3) Estrogen Receptor/ERR (4) Flavivirus (2) Fluorescent Dye (1) Fungal (4) GLUT (3) Glutathione Peroxidase (1) Glycosidase (137) HBV (2) HDAC (1) HIV (2) HMG-CoA Reductase (HMGCR) (1) Influenza Virus (2) Isotope-Labeled Compounds (1) JNK (1) Lipase (4) MMP (1) Monoamine Oxidase (3) Mucin (1) NF-κB (6) NO Synthase (1) NOD-like Receptor (NLR) (2) Notch (1) P2Y Receptor (1) p38 MAPK (2) Parasite (6) Phosphatase (4) Phosphodiesterase (PDE) (2) PKC (1) PPAR (5) Pregnane X Receptor (PXR) (2) Pyroptosis (2) Reactive Oxygen Species (ROS) (5) Reference Standards (18) SARS-CoV (2) SOD (1) TGF-beta/Smad (1) TGF-β Receptor (1) Toll-like Receptor (TLR) (1) Tyrosinase (2) VEGFR (1) α-synuclein (2) β-glucuronidase (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (4) Endocrinology (4) Infection (38) Inflammation/Immunology (32) Metabolic Disease (104) Neurological Disease (12)

By Targets:

Aldose Reductase (1)

Amylases (27)

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (4)

Apoptosis (10)

Aryl Hydrocarbon Receptor (3)

Aurora Kinase (1)

Bacterial (10)

Bcl-2 Family (1)

c-Kit (1)

Carbonic Anhydrase (2)

Cholinesterase (ChE) (5)

COX (3)

Dengue Virus (1)

Dipeptidyl Peptidase (5)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

Endogenous Metabolite (11)

Environmental Pollutants (3)

Estrogen Receptor/ERR (4)

Flavivirus (2)

Fluorescent Dye (1)

Fungal (4)

GLUT (3)

Glutathione Peroxidase (1)

Glycosidase (137)

HBV (2)

HDAC (1)

HIV (2)

HMG-CoA Reductase (HMGCR) (1)

Influenza Virus (2)

Isotope-Labeled Compounds (1)

JNK (1)

Lipase (4)

MMP (1)

Monoamine Oxidase (3)

Mucin (1)

NF-κB (6)

NO Synthase (1)

NOD-like Receptor (NLR) (2)

Notch (1)

P2Y Receptor (1)

p38 MAPK (2)

Parasite (6)

Phosphatase (4)

Phosphodiesterase (PDE) (2)

PKC (1)

PPAR (5)

Pregnane X Receptor (PXR) (2)

Pyroptosis (2)

Reactive Oxygen Species (ROS) (5)

Reference Standards (18)

SARS-CoV (2)

SOD (1)

TGF-beta/Smad (1)

TGF-β Receptor (1)

Toll-like Receptor (TLR) (1)

Tyrosinase (2)

VEGFR (1)

α-synuclein (2)

β-glucuronidase (1)

By Research Areas:

Cancer (32)

Cardiovascular Disease (4)

Endocrinology (4)

Infection (38)

Inflammation/Immunology (32)

Metabolic Disease (104)

Neurological Disease (12)

157

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132179

Fucoidan 5+ Cited Publications	Glycosidase	Cardiovascular Disease Metabolic Disease Cancer
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .

HY-W011411

4-Nitrophenyl a-D-glucopyranoside	Glycosidase	Others
4-Nitrophenyl a-D-glucopyranoside is a chromogenic substrate for α-glucosidase. 4-Nitrophenyl a-D-glucopyranoside can be used to measure of α-glucosidase activity .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Environmental Pollutants Apoptosis Parasite Endogenous Metabolite Bacterial Glycosidase	Infection Metabolic Disease Cancer
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of *α-glucosidase*. Hexylresorcinol has protective effects against oxidative DNA damage .

HY-N2574

Gitogenin 2 Publications Verification	Glycosidase	Metabolic Disease
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme *α-glucosidase* with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-112835

Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside pNP-G7	Amylases Glycosidase	Inflammation/Immunology
Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside (EPS; pNP-G7) serves as a substrate for α-amylase. In the presence of an auxiliary enzyme such as α-glucosidase (α-glucosidase), Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside is degraded by amylase (Amylase) to release a chromophore, enabling the measurement of amylase activity. Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside is applicable for the diagnosis of pancreatitis ^[2].

HY-N0419

Quercimeritrin 2 Publications Verification Quercetin-7-O-β-D-glucopyranoside	Glycosidase c-Kit MMP VEGFR Aurora Kinase	Metabolic Disease Cancer
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor (with an IC₅₀ of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .

HY-N2376

Chrysin-7-O-glucuronide 1 Publications Verification	Glycosidase Amylases NF-κB	Metabolic Disease Inflammation/Immunology
Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits *α-glucosidase* and α-amylase with IC₅₀ values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury .

HY-N1029

Norathyriol 3 Publications Verification Mangiferitin	Glycosidase PPAR	Infection Inflammation/Immunology Cancer
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits *α-glucosidase* in a noncompetitive manner with an IC₅₀ of 3.12 μM . Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC₅₀s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

HY-137873

4-Methylumbelliferyl-α-D-Glucopyranoside 4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside; 4-MU-α-D-Glucopyranoside	Fluorescent Dye Glycosidase	Others
4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose) is a fluorescent substrate for *α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-α-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase* activity in infant blood spot samples.

HY-113133

Kojibiose	Glycosidase	Infection Metabolic Disease Inflammation/Immunology
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .

HY-N4258

Panasenoside	Glycosidase	Metabolic Disease
Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits *α-glucosidase* inhibitory activity .

HY-N9317

Tangshenoside I	Glycosidase	Metabolic Disease
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC₅₀ of 1.4 mM .

HY-N7203

N-Caffeoyl O-methyltyramine	Glycosidase	Metabolic Disease
N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against *α-glucosidase* (IC₅₀ of 103.58 μM) .

HY-N7626

Eleutherol	Fungal Glycosidase	Infection
Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC₅₀>1.00 mM .

HY-119821

Terphenyllin	Glycosidase	Infection
Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has signiﬁcant *α-glucosidase* inhibitory activity .

HY-200541

Dihydro-α-ionone	Others	Metabolic Disease
Dihydro-α-ionone is a volatile compound found in the essential oil of Persicaria hydropiper L. leaves. The essential oil can inhibit α-glucosidase and α-amylase activities .

HY-N8517

Malabaricone B	Glycosidase Apoptosis	Infection Metabolic Disease Cancer
Malabaricone B, a naturally occurring plant phenolic, is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities .

HY-126535

Magnoloside B	Glycosidase	Metabolic Disease Cancer
Magnoloside B is an *α-glucosidase* inhibitor (IC₅₀=0.69 mM), which can be obtained from Magnolia officinalis stem bark. Magnoloside B shows moderate inhibitory activity against MGC-803 and HepG2 cells. Magnoloside B has the potential to study cancer and diabetes .

HY-N10413

Diphlorethohydroxycarmalol	Glycosidase	Metabolic Disease
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active *α-glucosidase* and α-amylase inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities .

HY-P2802D

exo-α-Glucosidase, Bacteroides thetaiotaomicron	Glycosidase	Others
exo-α-Glucosidase,Bacteroides thetaiotaomicron (EC.3.2.1.20) is a α-Glucosidase. exo-α-Glucosidase, using maltose as a donor, exhibits excellent transglycosidic activity towards various receptors .

HY-155241

α-Amylase/α-Glucosidase-IN-4	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-175605

α-Amylase/α-Glucosidase-IN-21	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-21 (Compound 4) is a dual-functional inhibitor of *α-Glucosidase* and α-Amylase with IC₅₀s of 0.27 and 0.19 µg/mL for α-Glucosidase and α-Amylase, respectively. α-Amylase/α-Glucosidase-IN-21 has an antidiabetic activity.α-Amylase/α-Glucosidase-IN-21 can be used for diabetes mellitus research .

HY-W127945

N-(E)-Caffeoyldopamine	Glycosidase	Metabolic Disease
N-(E)-Caffeoyldopamine is an inhibitor of *α-glucosidase* that can be purified from Clerodendranthus Spicatus. N-(E)-Caffeoyldopamine shows a 53.73% inhibitory activity againstα-glucosidase. N-(E)-Caffeoyldopamine can be studied in diabetes research .

HY-N3078

p-Hydroxyphenethyl trans-ferulate	Glycosidase	Endocrinology Cancer
p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast *α-glucosidase, IC₅₀=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities* . p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity .

HY-W112651

2,4,6-Triphenylaniline	Glycosidase Amylases	Metabolic Disease
2,4,6-Triphenylaniline has anti-diabetic activity and can be encapsulated in nano-emulsions (NE) to enhance stability and permeability. The NE loaded with 2,4,6-Triphenylaniline inhibits *α-glucosidase* and α-amylase .

HY-N0464S

Quinic acid-13C3	Isotope-Labeled Compounds Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-N10294

Epicoccone B	HIV	Infection Inflammation/Immunology
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N13188

2'-Rhamnoechinacoside Michelioside A	Glycosidase	Cancer
2'-Rhamnoechinacoside (Michelioside A), a compound of phenylethanoid glycosides, is a *α-glucosidase* inhibitor with anti-tumor activity, which is derived from Phlomis stewartii. 2'-Rhamnoechinacoside can be used for research of UV-absorbing and cancers .

HY-156078

α-Glucosidase-IN-32	Glycosidase	Metabolic Disease
α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC₅₀ value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research .

HY-149579

α-Glucosidase-IN-36	Glycosidase	Metabolic Disease
α-Glucosidase-IN-36 (compound 5g) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 6.69 ± 0.18 μM, K_i and K_is of 1.65 μM and 4.54 μM, respectively. α-Glucosidase-IN-36 may inhibit α-glucosidase activity by binding with its active site as well as changing the secondary structure of α-glucosidase. α-Glucosidase-IN-36 can be used for type 2 diabetes mellitus (T2DM) research .

HY-174319

α-Amylase/α-Glucosidase-IN-20	Amylases Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-20 (Compound 6b) is a dual inhibitor of α-Amylase and *α-Glucosidase* with IC₅₀s of 414.57 and 924.15 μM for α-Amylase and α-Glucosidase, respectively. α-Amylase/α-Glucosidase-IN-20 shows a potent anti-diabetic activity, promising for diabetes research .

HY-151142

α-Glucosidase-IN-18	Glycosidase	Metabolic Disease
α-Glucosidase-IN-18 (7B) is an orally active *α-glucosidase* inhibitor with an IC₅₀ value of 3.96 μM. α-Glucosidase-IN-18 has antidiabetic activity .

HY-151141

α-Glucosidase-IN-17	Glycosidase	Metabolic Disease
α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity .

HY-151135

α-Glucosidase-IN-15	Glycosidase	Metabolic Disease
α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity .

HY-151143

α-Glucosidase-IN-19	Glycosidase	Metabolic Disease
α-Glucosidase-IN-19 (Compound 6B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.63 μM. α-Glucosidase-IN-19 shows anti-diabetic activity .

HY-151145

α-Glucosidase-IN-21	Glycosidase	Metabolic Disease
α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity .

HY-151144

α-Glucosidase-IN-20	Glycosidase	Metabolic Disease
α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity .

HY-N12689

α-Glucosidase-IN-56	Glycosidase	Metabolic Disease
α-Glucosidase-IN-56 (compound 1) is an orally active, potent *α‐glucosidase* inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities .

HY-161522

α-Glucosidase-IN-63	Glycosidase Carbonic Anhydrase	Endocrinology
α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of *α-Glucosidase* (IC₅₀=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of K_i= 7.0 nM. α-Glucosidase-IN-63 is orally effective. .

HY-163066

α-Glucosidase-IN-44	Glycosidase	Metabolic Disease
α-Glucosidase-IN-44 (compound IT4) is an inhibitor of *α-glucosidase* with IC₅₀ value of 2.35 μM. α-Glucosidase-IN-44 has an oral activity. α-Glucosidase-IN-44 suppresses fasting blood glucose levels in diabetic mice .

HY-N12347

α-Glucosidase-IN-37	Others	Inflammation/Immunology
α-Glucosidase-IN-37 (Compound 11) moderately inhibits LPS-induced NO production with an IC₅₀ value of 23.7 μM in macrophages. α-Glucosidase-IN-37 has weak inhibitory activity against α-Glucosidase .

HY-N15138

Sativanone	Glycosidase	Infection Metabolic Disease Inflammation/Immunology
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent *α-glucosidase* inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

HY-165100

1,3-Dipalmitoleoyl glycerol DG(16:1/0:0/16:1); 1,3-Dipalmitolein	Glycosidase	Others
1,3-Dipalmitoleoyl glycerol (DG(16:1/0:0/16:1)) is a compound isolated from sea cucumber viscera, which has α-glucosidase inhibitory activity and has different degrees of inhibitory effects on α-glucosidase from different sources.

HY-149676

α-Glucosidase-IN-42	Glycosidase	Metabolic Disease
α-Glucosidase-IN-42 (Compound 26) is a 9-O-berberrubine carboxylate derivative. α-Glucosidase-IN-42 has potent α-glucosidase inhibitory activities with an IC₅₀ value in the range of 1.61 μM. α-Glucosidase-IN-42 can be used for the research of antidiabetic .

HY-149668

α-Glucosidase-IN-41	Glycosidase	Metabolic Disease
α-Glucosidase-IN-41 (compound 5o) is a potent *α-glucosidase* inhibitor. α-Glucosidase-IN-41 can arise the changed secondary structure of α-Glu to hinder enzyme catalytic activity. α-Glucosidase-IN-41 can be used for diabetes mellitus research .

HY-173183

α-Glucosidase-IN-87	Glycosidase	Metabolic Disease
α-Glucosidase-IN-87 (Compound 11c) is an orally active *α-glucosidase* inhibitor with an IC₅₀ value of 119.7 μM. α-Glucosidase-IN-87 has hypoglycemic activity and can be used in the research of metabolic diseases such as diabetes .

HY-149409

α-Glucosidase-IN-31	Glycosidase	Metabolic Disease
α-Glucosidase-IN-31 (compound R1) is an orally active, potent *α-Glucosidase* inhibitor with an IC₅₀ value of 10.1 μM. α-Glucosidase-IN-31 significantly reduces the blood glucose level and has antidiabetic activity .

HY-168462

α-Glucosidase-IN-82	Glycosidase	Metabolic Disease
α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of *α-Glucosidase, with the IC₅₀* of 13.66 μM. α-Glucosidase-IN-82 exhibits a 52-fold increase in inhibitory activity relative to Acarbose (HY-B0089) .

HY-151138

α-Glucosidase-IN-16	Glycosidase	Metabolic Disease
α-Glucosidase-IN-16 is a potent and orally active *α-glucosidase* inhibitor with an IC₅₀ value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin (HY-13753)-induced diabetic rats. Antidiabetic activity .

Cat. No.	Product Name	Target	Research Area

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Reference Standards Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-132179

Fucoidan 5+ Cited Publications	Brown seaweed Classification of Application Fields Marine natural products Whitening Agent Metabolic Disease Plants Polysaccharides other families Marine algae Cosmetic Research Disease Research Fields Saccharides Source Classification Cancer	Glycosidase
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .

HY-113159

Docosapentaenoic acid (22n-3) Clupanodonic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Amylases Glycosidase
Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and *α-glucosidase, with IC₅₀*s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect .

HY-N0058

4,5-Dicaffeoylquinic acid Maximum Cited Publications 11 Publications Verification Isochlorogenic acid C	Infection Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Disease Research Fields Source Classification	HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast *α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus* effects .

HY-N0057

3,4-Dicaffeoylquinic acid 5+ Cited Publications 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B	Infection Caprifoliaceae Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification	Glycosidase Influenza Virus Apoptosis Endogenous Metabolite
3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and *α-glucosidase* inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Infection Structural Classification Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis Parasite Endogenous Metabolite Bacterial Glycosidase
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of *α-glucosidase*. Hexylresorcinol has protective effects against oxidative DNA damage .

HY-N2574

Gitogenin 2 Publications Verification	Tribulus terrester Linn. Classification of Application Fields Zygophyllaceae Metabolic Disease Plants Disease Research Fields Steroids Source Classification	Glycosidase
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme *α-glucosidase* with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Infection Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-126052

Gnetol	Stilbenes Classification of Application Fields Phenols Polyphenols Gnetaceae Metabolic Disease Plants Disease Research Fields Gnetum montanum Markgr. Source Classification	COX Tyrosinase HDAC
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-N0419

Quercimeritrin 2 Publications Verification Quercetin-7-O-β-D-glucopyranoside	Flavonols Structural Classification Ginkgoaceae Classification of Application Fields Metabolic Disease Plants Compositae Endogenous metabolite Ginkgo biloba Human Gut Microbiota Metabolites Flavonoids Derris scandens Disease Research Fields Source Classification	Glycosidase c-Kit MMP VEGFR Aurora Kinase
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor (with an IC₅₀ of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .

HY-N2376

Chrysin-7-O-glucuronide 1 Publications Verification	Structural Classification Classification of Application Fields Flavones Plants Oroxylum indicum (Linn.) Bentham ex Kurz Monophenols Flavonoids Labiatae Other Diseases Phenols Bignoniaceae Medicago truncatula Gaertn. Disease Research Fields Source Classification	Glycosidase Amylases NF-κB
Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits *α-glucosidase* and α-amylase with IC₅₀ values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury .

HY-N1029

Norathyriol 3 Publications Verification Mangiferitin	Infection Human Gut Microbiota Metabolites Classification of Application Fields Phenols Polyphenols Mangifera indica Linn. Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Anacardiaceae Source Classification	Glycosidase PPAR
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits *α-glucosidase* in a noncompetitive manner with an IC₅₀ of 3.12 μM . Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC₅₀s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

HY-N2925

β-Amyrone 1 Publications Verification β-Amyron	Triterpenes Caprifoliaceae Plants Sambucus adnata Wall. ex DC. Source Classification	Fungal COX PPAR
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits *α-glucosidase* and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity .

HY-N2025

Oroxin A 4 Publications Verification	Flavonoids Classification of Application Fields Flavones Metabolic Disease Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Source Classification	PPAR Glycosidase
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against *α-glucosidase* and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-Y0790

Cuminaldehyde 1 Publications Verification p-Isopropylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Rudbeckia laciniata L. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants α-synuclein
Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-N2230

N-p-trans-Coumaroyltyramine	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Source Classification	Cholinesterase (ChE) Parasite Glycosidase
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC₅₀: 122 μM) and *α-glucosidase* (IC₅₀: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC₅₀ of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease .

HY-N8220

2-(2-Phenylethyl)chromone Flidersiachromone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Thymelaeaceae Other Diseases Plants Aquilaria sinensis (Lour.) Spreng. Disease Research Fields Source Classification	Glycosidase
2-(2-Phenylethyl) chromone (Flidersiachromone) is a chromone derivative and antioxidant. 2-(2-Phenylethyl) chromone scavenges ABTS· ⁺ free radicals, and its derivatives exhibit diverse activities including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. 2-(2-Phenylethyl) chromone is applicable to experimental research in fields such as inflammation-related diseases, tumors, and neurodegenerative diseases .

HY-N8599

Cichoriin 2 Publications Verification	Infection Structural Classification Monophenols other families Classification of Application Fields Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, *α-glucosidase, pancreatic lipase* and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀ = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-113133

Kojibiose	Microorganisms Source Classification	Glycosidase
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .

HY-N4095

Brevifolincarboxylic acid	Structural Classification Natural Products Classification of Application Fields Polygonaceae Metabolic Disease Plants other families Phenols Polyphenols Polygonum capitatum Buch.-Ham. ex D. Don Prodr Inflammation/Immunology Disease Research Fields Source Classification	Aryl Hydrocarbon Receptor Glycosidase Reactive Oxygen Species (ROS) GLUT
Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits *α-glucosidase* with an IC₅₀ value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases .

HY-N3405

Lariciresinol 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Lignans Arabidopsis thaliana Phenylpropanoids Plants Brassicaceae Endogenous metabolite Source Classification	Glycosidase Bcl-2 Family Apoptosis TGF-β Receptor NF-κB Fungal
Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits *α-glucosidase* activity (IC₅₀ of 6.97 μM; K_i of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Cardiovascular Disease Monophenols other families Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N1510

Kaempferol 3-O-gentiobioside	Flavonols Structural Classification Flavonoids Sauropus spatulifolius Beille Classification of Application Fields Phenols Polyphenols Metabolic Disease Euphorbiaceae Plants Disease Research Fields Source Classification	Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)
Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a K_a value of 57 µM against human NOTCH1 and an IC₅₀ value of 50 μM against *α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH* signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .

HY-N4258

Panasenoside	Panax ginseng C. A. Meyer Flavonols Classification of Application Fields Metabolic Disease Plants Lilium pumilum DC. Flavonoids Liliaceae Phenols Polyphenols Disease Research Fields Araliaceae Source Classification	Glycosidase
Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits *α-glucosidase* inhibitory activity .

HY-N9317

Tangshenoside I	Classification of Application Fields Ketones, Aldehydes, Acids Campanulaceae Metabolic Disease Codonopsis lanceolata (Sieb. et Zucc.) Trautv. Plants Disease Research Fields Source Classification	Glycosidase
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC₅₀ of 1.4 mM .

HY-N7203

N-Caffeoyl O-methyltyramine	Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Metabolic Disease Plants Annonaceae Disease Research Fields Source Classification Fissistigma oldhamii (Hemsl.) Merr.	Glycosidase
N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against *α-glucosidase* (IC₅₀ of 103.58 μM) .

HY-N7626

Eleutherol	Infection Monophenols Iridaceae Classification of Application Fields Phenols Eleutherine plicata Herb. Plants Disease Research Fields Source Classification	Fungal Glycosidase
Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC₅₀>1.00 mM .

HY-N2821

(+)-Afzelechin 4 Publications Verification	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Metabolic Disease Plants Saxifragaceae Disease Research Fields Source Classification	Glycosidase
(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an *alpha-glucosidase* activity inhibitor with an ID₅₀ (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia .

HY-N4309

Lotusine	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Amylases Glycosidase
Lotusine is an orally active signaling pathway modulator and enzyme inhibitor, with an IC₅₀ of 30.60 μg/mL against α-amylase and an IC₅₀ of 36.15 μg/mL against *α-glucosidase. Lotusine inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine induces apoptosis, triggers G₀/G₁ cell cycle arrest and inhibits cancer cell proliferation. Lotusine reduces lipid peroxidation and increases the activities* of SOD, CAT and GPx. Lotusine is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder .

HY-119741

Salacinol	Structural Classification Natural Products Salacia reticulata Wight Celastraceae Plants Source Classification	Glycosidase Lipase
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-119821

Terphenyllin	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	Glycosidase
Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has signiﬁcant *α-glucosidase* inhibitory activity .

HY-200541

Dihydro-α-ionone	Structural Classification Ketones, Aldehydes, Acids Aucklandia costus Falc. Asteraceae Plants Source Classification	Others
Dihydro-α-ionone is a volatile compound found in the essential oil of Persicaria hydropiper L. leaves. The essential oil can inhibit α-glucosidase and α-amylase activities .

HY-N8517

Malabaricone B	Infection Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Disease Research Fields Cancer Source Classification	Glycosidase Apoptosis
Malabaricone B, a naturally occurring plant phenolic, is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities .

HY-126535

Magnoloside B	Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Plants Source Classification	Glycosidase
Magnoloside B is an *α-glucosidase* inhibitor (IC₅₀=0.69 mM), which can be obtained from Magnolia officinalis stem bark. Magnoloside B shows moderate inhibitory activity against MGC-803 and HepG2 cells. Magnoloside B has the potential to study cancer and diabetes .

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard) Isochlorogenic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Source Classification	Reference Standards HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N9454

Garcinoic acid	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Source Classification Cancer	Pregnane X Receptor (PXR) COX NF-κB Amylases β-glucuronidase DNA/RNA Synthesis Amyloid-β NOD-like Receptor (NLR) Pyroptosis
Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2, porcine α-amylase, Saccharomyces cerevisiae *α-glucosidase* and human DNA polymerase β (IC₅₀=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia .

HY-N10413

Diphlorethohydroxycarmalol	other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification Ishige okamurae	Glycosidase
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active *α-glucosidase* and α-amylase inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-W127945

N-(E)-Caffeoyldopamine	Labiatae Phenols Polyphenols Plants Swartzia polyphylla DC. Source Classification	Glycosidase
N-(E)-Caffeoyldopamine is an inhibitor of *α-glucosidase* that can be purified from Clerodendranthus Spicatus. N-(E)-Caffeoyldopamine shows a 53.73% inhibitory activity againstα-glucosidase. N-(E)-Caffeoyldopamine can be studied in diabetes research .

HY-N3078

p-Hydroxyphenethyl trans-ferulate	Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Endocrinology Source Classification	Glycosidase
p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast *α-glucosidase, IC₅₀=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities* . p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity .

HY-129149

Ganoderic acid SZ	Microorganisms Ketones, Aldehydes, Acids Source Classification	HMG-CoA Reductase (HMGCR)
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .

HY-N0057R

3,4-Dicaffeoylquinic acid (Standard) 3,4-Di-O-caffeoylquinic acid (Standard); Isochlorogenic acid B (Standard)	Structural Classification Caprifoliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Glycosidase Influenza Virus Apoptosis Endogenous Metabolite
3,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 3,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL .

HY-N16523

Ferruginoside C	Plantaginaceae Structural Classification Phenols Polyphenols Plantago asiatica L. Plants Source Classification	Glycosidase
Ferruginoside C is a phenylethanoid. Ferruginoside C can be isolated from V. leiocarpum. Ferruginoside C shows potent *alpha-glucosidase* inhibitory activity with an IC₅₀ of 19.93 μM. Ferruginoside C shows antioxidant activities. Ferruginoside C can be used in the research of cervical cancer, ovarian cancer, and colon cancer .

HY-Y0790R

Cuminaldehyde (Standard) p-Isopropylbenzaldehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Rudbeckia laciniata L. Umbelliferae Plants Endogenous metabolite Source Classification	α-synuclein Reference Standards
Cuminaldehyde Standard is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL) and α-glucosidase (IC₅₀=0.5 mg/mL). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-N10294

Epicoccone B	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Inflammation/Immunology Source Classification	HIV
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N13188

2'-Rhamnoechinacoside Michelioside A	Magnoliaceae Phenols Polyphenols Plants Michelia yunnanensis Franch. ex Finet & Gagnep. Source Classification	Glycosidase
2'-Rhamnoechinacoside (Michelioside A), a compound of phenylethanoid glycosides, is a *α-glucosidase* inhibitor with anti-tumor activity, which is derived from Phlomis stewartii. 2'-Rhamnoechinacoside can be used for research of UV-absorbing and cancers .

HY-N12689

α-Glucosidase-IN-56	Pistacia chinensis Bunge Phenols Polyphenols Plants Anacardiaceae Source Classification	Glycosidase
α-Glucosidase-IN-56 (compound 1) is an orally active, potent *α‐glucosidase* inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities .

HY-N12347

α-Glucosidase-IN-37	Ketones, Aldehydes, Acids Amomum villosum Lour. Plants Source Classification Zingiberaceae	Others
α-Glucosidase-IN-37 (Compound 11) moderately inhibits LPS-induced NO production with an IC₅₀ value of 23.7 μM in macrophages. α-Glucosidase-IN-37 has weak inhibitory activity against α-Glucosidase .

HY-N15138

Sativanone	Flavonoids Dalbergia tonkinensis Prain Leguminosae Isoflavanones Plants Source Classification	Glycosidase
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent *α-glucosidase* inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

HY-N12761

Penpaxilloids A	Terpenoids Marine natural products Diterpenoids Marine microorganism Source Classification	Phosphatase Glycosidase
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .

HY-N13137

Timosaponin N	Structural Classification Liliaceae Anemarrhena asphodeloides Bunge Plants Steroids Source Classification	Glycosidase
Timosaponin N is a natural steroidal saponin that inhibits the activity of *α-Glucosidase*. Timosaponin N can be used in diabetes-related research .

Cat. No.	Product Name	Chemical Structure

HY-N0464S

Quinic acid-13C3
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

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