179 Results for "

α-glucosidase activity

" in MedChemExpress (MCE) Product Catalog:
Products (179)

179 Results for "α-glucosidase activity" in MCE Product Catalog:

12
4,5-Dicaffeoylquinic acid
4,5-Dicaffeoylquinic acid
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12 Publications Verification
Cat. No.: HY-N0058
CAS No.: 57378-72-0
Synonyms: Isochlorogenic acid C; 4,5-diCQA
Category:  

Infection Ketones, Aldehydes, Acids Phenols Polyphenols Plants Bowdichia virgilioides Compositae Endogenous metabolite Disease Research Fields

Target:  

HBV Endogenous Metabolite Apoptosis Glycosidase

4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .
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10
3,4-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid
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10 Cited Publications
Cat. No.: HY-N0057
CAS No.: 14534-61-3
Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B
Category:  

Infection Caprifoliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields

Target:  

Free Radical Scavengers Glycosidase Influenza Virus Apoptosis Endogenous Metabolite

3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL .
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9
Fucoidan
Fucoidan
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9 Cited Publications
Cat. No.: HY-132179
CAS No.: 9072-19-9
Purity:  ≥98.0%
Category:  

Brown seaweed Whitening Agent Marine natural products Metabolic Disease Plants other families Polysaccharides Marine algae Cosmetic Research Disease Research Fields Saccharides Cancer

Target:  

Glycosidase

Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .
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4
Oroxin A
Oroxin A
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4 Cited Publications
Cat. No.: HY-N2025
CAS No.: 57396-78-8
Category:  

Flavonoids Flavones Metabolic Disease Plants Bignoniaceae Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields

Target:  

PPAR Glycosidase

Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .
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4
(+)-Afzelechin
(+)-Afzelechin
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4 Cited Publications
Cat. No.: HY-N2821
CAS No.: 2545-00-8
Category:  

Flavonoids Flavanols Metabolic Disease Phenols Polyphenols Plants Saxifragaceae Disease Research Fields

Target:  

Glycosidase

(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia .
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3
D-(-)-Quinic acid
D-(-)-Quinic acid
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3 Cited Publications
Cat. No.: HY-N0464
CAS No.: 77-95-2
Category:  

Infection other families Microorganisms Ketones, Aldehydes, Acids Plants Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Glycosidase Monoamine Oxidase

D-(-)-Quinic acid scavenges hydrogen peroxide (IC50=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC50 =93.75 μg/mL). D-(-)-Quinic acid is orally active .
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3
Norathyriol
Norathyriol
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3 Cited Publications
Cat. No.: HY-N1029
CAS No.: 3542-72-1
Synonyms: Mangiferitin
Category:  

Mangifera indica Linn. Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Phenols Polyphenols Disease Research Fields Inflammation/Immunology Anacardiaceae

Target:  

Glycosidase PPAR

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM . Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
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2
Quercimeritrin
Quercimeritrin
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2 Cited Publications
Cat. No.: HY-N0419
CAS No.: 491-50-9
Synonyms: Quercetin-7-O-β-D-glucopyranoside
Category:  

Flavonols Ginkgoaceae Metabolic Disease Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Derris scandens Ginkgo biloba L. Disease Research Fields

Target:  

Glycosidase c-Kit MMP VEGFR Aurora Kinase

Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor (with an IC50 of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .
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2
Gitogenin
Gitogenin
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2 Cited Publications
Cat. No.: HY-N2574
CAS No.: 511-96-6
Category:  

Tribulus terrester Linn. Zygophyllaceae Metabolic Disease Plants Disease Research Fields Steroids

Target:  

Glycosidase

Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .
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2
Cichoriin
Cichoriin
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2 Cited Publications
Cat. No.: HY-N8599
CAS No.: 531-58-8
Category:  

Infection other families Monophenols Coumarins Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB

Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .
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1
Chrysin-7-O-glucuronide
Chrysin-7-O-glucuronide
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1 Cited Publications
Cat. No.: HY-N2376
CAS No.: 35775-49-6
Category:  

Flavones Plants Oroxylum indicum (Linn.) Bentham ex Kurz Flavonoids Monophenols Labiatae Other Diseases Phenols Bignoniaceae Disease Research Fields Medicago truncatula Gaertn.

Target:  

Glycosidase Amylases NF-κB

Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury .
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1
Kojibiose
Kojibiose
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1 Cited Publications
Cat. No.: HY-113133
CAS No.: 2140-29-6
Purity:  99.76%
Category:  

Polysaccharides Microorganisms Saccharides

Target:  

Glycosidase

Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .
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1
β-Amyrone
β-Amyrone
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1 Cited Publications
Cat. No.: HY-N2925
CAS No.: 638-97-1
Synonyms: β-Amyron
Category:  

Triterpenes Caprifoliaceae Plants Sambucus adnata Wall. ex DC.

Target:  

Fungal COX PPAR

β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity .
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1
N-p-trans-Coumaroyltyramine
N-p-trans-Coumaroyltyramine
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1 Cited Publications
Cat. No.: HY-N2230
CAS No.: 36417-86-4
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants

Target:  

Cholinesterase (ChE) Parasite Glycosidase

N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease .
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1
Lariciresinol
Lariciresinol
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1 Cited Publications
Cat. No.: HY-N3405
CAS No.: 27003-73-2
Category:  

Human Gut Microbiota Metabolites Lignans Arabidopsis thaliana Phenylpropanoids Plants Brassicaceae Endogenous metabolite

Target:  

Glycosidase Bcl-2 Family Apoptosis TGF-β Receptor NF-κB Fungal

Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 μM; Ki of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity .
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1
Pinoresinol 4-O-β-D-glucopyranoside
Pinoresinol 4-O-β-D-glucopyranoside
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1 Cited Publications
Cat. No.: HY-N2168
CAS No.: 69251-96-3
Synonyms: (+)-Pinoresinol 4-O-β-D-glucopyranoside
Category:  

Cardiovascular Disease other families Monophenols Lignans Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Glycosidase Free Radical Scavengers Estrogen Receptor/ERR Phosphodiesterase (PDE)

Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .
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1
Cuminaldehyde
Cuminaldehyde
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1 Cited Publications
Cat. No.: HY-Y0790
CAS No.: 122-03-2
Synonyms: p-Isopropylbenzaldehyde
Category:  

Rudbeckia laciniata L. Ketones, Aldehydes, Acids Plants Umbelliferae Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants α-synuclein

Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
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1
Petunidin-3-O-glucoside chloride
Petunidin-3-O-glucoside chloride
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1 Cited Publications
Cat. No.: HY-N7832
CAS No.: 6988-81-4
Category:  

Anthocyans Flavonoids Metabolic Disease Myrtaceae Phenols Polyphenols Rhodomyrtus tomentosa Plants Disease Research Fields

Target:  

Tyrosinase Glycosidase Apoptosis PI3K Akt ERK Reactive Oxygen Species (ROS) MDM-2/p53

Petunidin-3-O-glucoside chloride is a blood-brain barrier-penetrating tyrosinase inhibitor with an IC50 of 10.3 μM and a Ki of 9.0 μM. Petunidin-3-O-glucoside also acts as an α-glucosidase inhibitor with an IC50 of 218.2 µM. Petunidin-3-O-glucoside chloride inhibits the SIRT3/p53-mediated mitochondrial pathway and the PI3K/Akt-ERK pathway, suppresses glycolysis, and induces cell apoptosis. Petunidin-3-O-glucoside chloride scavenges ROS to exert antioxidant activity. It can be used in research related to glioblastoma multiforme, skin anti-aging and whitening, as well as obesity .
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4-Nitrophenyl a-D-glucopyranoside
4-Nitrophenyl a-D-glucopyranoside
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Cat. No.: HY-W011411
CAS No.: 3767-28-0
Target:  

Glycosidase

Research Areas:  

Others

4-Nitrophenyl a-D-glucopyranoside is a chromogenic substrate for α-glucosidase. 4-Nitrophenyl a-D-glucopyranoside can be used to measure of α-glucosidase activity .
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Hexylresorcinol
Hexylresorcinol
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Cat. No.: HY-B0986
CAS No.: 136-77-6
Synonyms: 4-Hexylresorcinol
Category:  

Infection Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants Apoptosis Parasite Endogenous Metabolite Bacterial Glycosidase

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .
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