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Results for "

Selective COX-2 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (175) Akt (2) Aldose Reductase (1) Amylases (1) Amyloid-β (1) Apoptosis (16) Autophagy (5) Bacterial (8) Bcl-2 Family (2) Biochemical Assay Reagents (3) Calcium Channel (1) Caspase (3) CFTR (4) Cholinesterase (ChE) (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Intermediate (5) Drug Metabolite (6) EGFR (3) Endogenous Metabolite (19) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4) Environmental Pollutants (1) ERK (1) Ferroptosis (1) Fluorescent Dye (1) Fungal (2) HDAC (1) Histone Acetyltransferase (8) Interleukin Related (8) Isotope-Labeled Compounds (24) JNK (2) Lipoxygenase (7) Melatonin Receptor (5) Microtubule/Tubulin (1) Mitophagy (5) MMP (2) Monoamine Oxidase (2) NF-κB (5) NO Synthase (6) NOD-like Receptor (NLR) (1) p38 MAPK (3) PANoptosis (1) Parasite (8) PERK (2) PGE synthase (4) PI3K (2) PPAR (1) Pregnane X Receptor (PXR) (1) Progesterone Receptor (3) Prostaglandin Receptor (5) Pyroptosis (1) Reactive Oxygen Species (ROS) (8) Reference Standards (35) SARS-CoV (1) Steroid Sulfatase (1) TNF Receptor (5) VEGFR (2) β-glucuronidase (1)
By Research Areas:	Cancer (70) Cardiovascular Disease (5) Endocrinology (3) Infection (13) Inflammation/Immunology (168) Metabolic Disease (8) Neurological Disease (33)

By Targets:

COX (175)

Akt (2)

Aldose Reductase (1)

Amylases (1)

Amyloid-β (1)

Apoptosis (16)

Autophagy (5)

Bacterial (8)

Bcl-2 Family (2)

Biochemical Assay Reagents (3)

Calcium Channel (1)

Caspase (3)

CFTR (4)

Cholinesterase (ChE) (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug Intermediate (5)

Drug Metabolite (6)

EGFR (3)

Endogenous Metabolite (19)

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4)

Environmental Pollutants (1)

ERK (1)

Ferroptosis (1)

Fluorescent Dye (1)

Fungal (2)

HDAC (1)

Histone Acetyltransferase (8)

Interleukin Related (8)

Isotope-Labeled Compounds (24)

JNK (2)

Lipoxygenase (7)

Melatonin Receptor (5)

Microtubule/Tubulin (1)

Mitophagy (5)

MMP (2)

Monoamine Oxidase (2)

NF-κB (5)

NO Synthase (6)

NOD-like Receptor (NLR) (1)

p38 MAPK (3)

PANoptosis (1)

Parasite (8)

PERK (2)

PGE synthase (4)

PI3K (2)

PPAR (1)

Pregnane X Receptor (PXR) (1)

Progesterone Receptor (3)

Prostaglandin Receptor (5)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (8)

Reference Standards (35)

SARS-CoV (1)

Steroid Sulfatase (1)

TNF Receptor (5)

VEGFR (2)

β-glucuronidase (1)

By Research Areas:

Cancer (70)

Cardiovascular Disease (5)

Endocrinology (3)

Infection (13)

Inflammation/Immunology (168)

Metabolic Disease (8)

Neurological Disease (33)

207

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14398

Celecoxib 60+ Cited Publications SC 58635	COX	Infection Neurological Disease Inflammation/Immunology Cancer
Celecoxib,a selective and BBB-permeable non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-B0363

Nimesulide 5+ Cited Publications R805	COX	Inflammation/Immunology Cancer
Nimesulide is a selective *COX-2* inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-17372

Rofecoxib 5 Publications Verification MK 966	COX	Inflammation/Immunology Cancer
Rofecoxib is a potent, specific and orally active *COX-2* inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-W015007

Metyrosine	COX	Cardiovascular Disease
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-15762

Valdecoxib 5 Publications Verification SC 65872	COX Endogenous Metabolite	Inflammation/Immunology Cancer
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2* and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-15321

Etoricoxib MK-0663; L-791456	COX	Inflammation/Immunology Cancer
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active *COX-2* inhibitor. Etoricoxib can cross the blood-brain barrier, with IC₅₀s of 1.1 μM and 116 μM for *COX-2* and COX-1 in human whole blood .

HY-B0335

Tolfenamic Acid 2 Publications Verification GEA 6414	COX	Infection Neurological Disease Inflammation/Immunology Cancer
Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits *COX-2, with an IC₅₀* of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-113083

Acetaminophen glucuronide APAP-glu	Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-114200

Imrecoxib BAP-909	COX	Inflammation/Immunology
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC₅₀ value of 18 nM, it also inhibits COX1- activity with an IC₅₀ value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect .

HY-14445

FK 3311 COX-2 inhibitor V	COX	Inflammation/Immunology
FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of *COX-2* with antiinflammatory agent.

HY-D0053

6-ROX 6-Carboxy-X-rhodamine	Fluorescent Dye	Others
6-ROX is a selective fluorescent probe and potential inhibitor of *COX-2. 6-ROX binds to the active site of COX-2* and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 .

HY-14670

Firocoxib ML 1785713	COX	Inflammation/Immunology
Firocoxib (ML 1785713) is a potent, selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for *COX-2* than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects .

HY-Y1100

Cyclopropylmethyl bromide	Drug Intermediate	Inflammation/Immunology
Cyclopropylmethyl bromide is an intermediate. Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670). Firocoxib (ML 1785713) is a potent, selective, orally active *COX-2* inhibitor .

HY-N0929

Hexahydrocurcumin	COX Reactive Oxygen Species (ROS)	Cancer
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-118078

Robenacoxib	COX	Inflammation/Immunology
Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective *COX-2* inhibitor .

HY-121537

CAY10404	COX Akt Apoptosis	Neurological Disease Inflammation/Immunology Cancer
CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 1 nM and a selectivity index (SI; COX-1 IC₅₀/COX-2 IC₅₀) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .

HY-103387

DuP-697 1 Publications Verification	COX Apoptosis	Inflammation/Immunology Cancer
DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active *COX-2* inhibitor (IC₅₀ of 10 nM and 800 nM for human *COX-2* and COX-1, respectively). DuP-697 exerts antiproliferative (IC₅₀ of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects .

HY-14398S

Celecoxib-d7 SC 58635-d₇	COX	Inflammation/Immunology Cancer
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-14398R

Celecoxib (Standard) SC 58635 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Celecoxib (Standard) is the analytical standard of Celecoxib. This product is intended for research and analytical applications. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-15321S

Etoricoxib-d4 1 Publications Verification MK-0663-d₄; L-791456-d₄	COX	Others
Etoricoxib-d₄ (MK-0663-d₄) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-118139

Desmethyl Celecoxib	COX	Inflammation/Immunology
Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75% .

HY-119447

Mavacoxib	COX	Inflammation/Immunology
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-66005S2

Acetaminophen-d7 Paracetamol-d₇; 4-Acetamidophenol-d₇; 4'-Hydroxyacetanilide-d₇	COX Endogenous Metabolite Histone Acetyltransferase	Inflammation/Immunology
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-U00129

SC57666	COX	Inflammation/Immunology
SC57666 is a selective *COX2* inhibitor with an IC₅₀ of 26 nM.

HY-14398S1

Celecoxib-d3 SC 58635-d₃	COX	Inflammation/Immunology Cancer
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-101655

COX-2-IN-2	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible *COX2* inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-134234

Celecoxib carboxylic acid	COX	Others
Celecoxib carboxylic acid is a metabolite of celecoxib (HY-14398). Celecoxib is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-B0335R

Tolfenamic Acid (Standard) GEA 6414 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Tolfenamic Acid (Standard) is the analytical standard of Tolfenamic Acid. This product is intended for research and analytical applications. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits *COX-2, with an IC₅₀* of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-119304

GW-406381	COX	Neurological Disease Inflammation/Immunology
GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury .

HY-U00239

SC58451	COX	Inflammation/Immunology
SC58451 is a potent and selective *Cox-2* inhibitor.

HY-138128

Acetaminophen mercapturate	Drug Metabolite	Inflammation/Immunology
Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor .

HY-150550

COX-2-IN-26	COX	Inflammation/Immunology
COX-2-IN-26 is a potent, selective and orally active *COX-2* inhibitor with IC₅₀ values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile .

HY-162167

COX-1-IN-1	COX	Cardiovascular Disease Neurological Disease
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC₅₀s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC₅₀/COX-1 IC₅₀) is 217. COX-1-IN-1 inhibits platelet aggregation .

HY-U00197

Tilmacoxib JTE522; JTP19605; RWJ57504	COX	Inflammation/Immunology
Tilmacoxib (JTE522) is a highly selective, time-dependent and irreversible human *COX-2* inhibitor with an IC₅₀ of 85 nM in an enzyme assay.

HY-179125

COX-2-IN-59	COX Bcl-2 Family Caspase Apoptosis	Cancer
COX-2-IN-59 is a potent and selective *COX-2* inhibitor with an IC₅₀ of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC₅₀ = 11.16 μM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer .

HY-17372S

Rofecoxib-d5	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .

HY-14670S

Firocoxib-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Firocoxib-d₄ (ML 1785713-d₄) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects .

HY-146370

COX-2-IN-12	COX	Inflammation/Immunology
COX-2-IN-12 (compound 3b) is a potent and selective inhibitor of *COX-2* with an IC₅₀ of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent. COX-2-IN-12 shows safety in-vivo acute toxicity study .

HY-W792524

Methosulide	COX	Inflammation/Immunology
Methosulide (Compound 1d) is a selective *COX-2* inhibitor with an IC₅₀ value of 2.31 μM. Methosulide can be used in the research of inflammatory diseases .

HY-15321S2

Etoricoxib-d3 MK-0663-d₃; L-791456-d₃	COX	Inflammation/Immunology
Etoricoxib-d₃ is the deuterium labeled Etoricoxib . Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood .

HY-15321R

Etoricoxib (Standard) MK-0663 (Standard); L-791456 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Etoricoxib (Standard) is the analytical standard of Etoricoxib. This product is intended for research and analytical applications. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active *COX-2* inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0335S1

Tolfenamic acid-13C6 GEA 6414-¹³C₆	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-118078R

Robenacoxib (Standard)	COX Reference Standards	Inflammation/Immunology
Robenacoxib (Standard) is the analytical standard of Robenacoxib. This product is intended for research and analytical applications. Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective *COX-2* inhibitor .

HY-108019

SD 8381	COX	Inflammation/Immunology
SD 8381 is a potent and selective *COX-2* inhibitor. SD 8381 shows IC₅₀ values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1 .

HY-14398G

Celecoxib SC 58635	COX	Inflammation/Immunology
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-162173

WYZ90	COX	Inflammation/Immunology
WYZ90 ((compound 6a) is a potent and selective *COX-2* inhibitor with IC₅₀ values of 75, 5734, 19940 nM for COX-2, COX-1 and DPPH, respectively. WYZ90 shows antioxidant and analgesic activity .

HY-177319

COX-2-IN-56	COX	Inflammation/Immunology
COX-2-IN-56 (example 6) is a selective *COX-2* inhibitor without significantly inhibiting COX-1. COX-2-IN-56 can be used for the study of COX-2 dependent disorders, such as inflammation .

HY-14445R

FK 3311 (Standard) COX-2 inhibitor V (Standard)	COX Reference Standards	Inflammation/Immunology
FK 3311 (Standard) is the analytical standard of FK 3311. This product is intended for research and analytical applications. FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of COX-2 with antiinflammatory agent.

HY-116610

L 748780	COX	Inflammation/Immunology
L 748780 (compound 2) is a selectivity *COX-2* inhibitor with the IC₅₀ values of 0.5 μM and ＞ 100 μM for COX-2 and COX-1, respectively .

HY-115936

COX-2-IN-9	COX	Inflammation/Immunology
COX-2-IN-9 (compound 7a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 10.17 uM. COX-2-IN-9 has higher COX-2 selectivity than Celecoxib. COX-2-IN-9 shows good in vivo anti-inflammatory and low ulcerogenic activity .

Cat. No.	Product Name

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

627 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 627 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

Cat. No.	Product Name	Type

HY-D0053

6-ROX 6-Carboxy-X-rhodamine	Fluorescent Dyes
6-ROX is a selective fluorescent probe and potential inhibitor of *COX-2. 6-ROX binds to the active site of COX-2* and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 .

HY-14398G

Celecoxib SC 58635	Fluorescent Dyes
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Fluorescent Dyes
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Type

HY-W251428

Phosphatidylglycerols (egg) sodium salt

Egg PG

Biochemical Assay Reagents

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

HY-Y1100

Cyclopropylmethyl bromide	Biochemical Assay Reagents
Cyclopropylmethyl bromide is an intermediate. Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670). Firocoxib (ML 1785713) is a potent, selective, orally active *COX-2* inhibitor .

HY-14398G

Celecoxib SC 58635	Biochemical Assay Reagents
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Biochemical Assay Reagents
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-66005

Acetaminophen 65+ Cited Publications Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite COX Histone Acetyltransferase Parasite Bacterial Ferroptosis
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .

HY-B0075

Melatonin Maximum Cited Publications 137 Publications Verification N-Acetyl-5-methoxytryptamine	Structural Classification Natural Products Other disease Neurological Disease Classification of Application Fields Anti-aging Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis PANoptosis
Melatonin is a hormone made by the pineal gland that can activate melatonin receptor and inhibit PANoptosis. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through *COX-2* downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-15762

Valdecoxib 5 Publications Verification SC 65872	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2* and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N1312

Sinapaldehyde	Infection Structural Classification Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification	COX Bacterial Reactive Oxygen Species (ROS) Interleukin Related NO Synthase PERK JNK
Sinapaldehyde is a methoxyphenol and a selective *COX-2* inhibitor (IC₅₀: 47.8 µM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge DPPH free radicals (IC₅₀: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria .

HY-113083

Acetaminophen glucuronide APAP-glu	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N0396

Harpagoside 4 Publications Verification	Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Harpagophytum procumbens Inflammation/Immunology Disease Research Fields	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and *COX-2* active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-N0929

Hexahydrocurcumin	Classification of Application Fields Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae Cancer	COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N0389

Columbin 1 Publications Verification	other families Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-B0075R

Melatonin (standard) Maximum Cited Publications 137 Publications Verification N-Acetyl-5-methoxytryptamine (standard); Melatonin	Structural Classification Natural Products Microorganisms Other disease Disease markers Endogenous metabolite Source Classification	Reference Standards Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis
Melatonin (Standard) is the analytical standard of Melatonin. This product is intended for research and analytical applications. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-N1965

Gaultherin	other families Classification of Application Fields Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK COX Monoamine Oxidase MMP Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, *COX-2* (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

HY-N9454

Garcinoic acid	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Source Classification Cancer	Pregnane X Receptor (PXR) COX NF-κB Amylases β-glucuronidase DNA/RNA Synthesis Amyloid-β NOD-like Receptor (NLR) Pyroptosis
Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human *COX-2, porcine α-amylase, Saccharomyces cerevisiae α-glucosidase* and human DNA polymerase β (IC₅₀=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia .

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N1312R

Sinapaldehyde (Standard)	Structural Classification Monophenols other families Phenols Plants Source Classification	Reference Standards COX Bacterial Reactive Oxygen Species (ROS) Interleukin Related NO Synthase PERK JNK
Sinapaldehyde is a methoxyphenol and a selective COX-2 inhibitor (IC50: 47.8 µM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge DPPH free radicals (IC50: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria .

HY-N0389R

Columbin (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards COX Parasite
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-N11880

2-O-Sinapoyl makisterone A	Fibraurea recisa Pierre Plants Menispermaceae Steroids Source Classification	COX
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-15762R

Valdecoxib (Standard) SC 65872 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards COX Endogenous Metabolite
Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2* and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N3866

Esculentic acid	Triterpenes Terpenoids Labiatae Plants Source Classification Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	COX
Esculentic acid is a selective *COX-2* inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-113083R

Acetaminophen glucuronide (Standard) APAP-glu (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-113027R

p-Hydroxymandelic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Melatonin (Standard) is the analytical standard of Melatonin. This product is intended for research and analytical applications. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-N0396R

Harpagoside (Standard)	Structural Classification Iridoids Terpenoids Pedaliaceae Plants Harpagophytum procumbens	Reference Standards COX NO Synthase
Harpagoside (Standard) is the analytical standard of Harpagoside. This product is intended for research and analytical applications. Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) .

HY-N1965R

Gaultherin (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Source Classification	Reference Standards NF-κB p38 MAPK COX Reactive Oxygen Species (ROS) Monoamine Oxidase MMP Interleukin Related TNF Receptor
Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965). Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, *COX-2* (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

HY-N16849

Myristinin A YM 26567-1	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit *COX-2* activity with an IC₅₀ of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC₅₀ of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .

HY-N16865

Myristinin B/C	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit *COX-2* activity with an IC₅₀ of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candida albicans with an IC₅₀ of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis .

HY-N17131

24-O-Acetyllycoclavanol	Lycopodiaceae Triterpenes Structural Classification Ketones, Aldehydes, Acids Terpenoids Plants Source Classification	NF-κB ERK
24-O-Acetyllycoclavanol (compound 1) is a triterpenoid anti-inflammatory agent that selectively targets the NF-κB and ERK1/2 signaling pathways. It exerts its anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and *COX-2* expression, reducing the production of inflammatory mediators such as nitric oxide (NO), IL-1β, and IL-8. 24-O-Acetyllycoclavanol can be used in research related to inflammatory bowel disease (IBD). 24-O-Acetyllycoclavanol can be biologically isolated from the ethyl acetate extract of Lycopodium clavatum .

Cat. No.	Product Name	Chemical Structure

HY-B0075S

Melatonin-d4
Melatonin-d₄ is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties . Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation .

HY-66005S

Acetaminophen-d4
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0075S1

Melatonin-d3

Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-66005S1

Acetaminophen-d3
Acetaminophen-d₃ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0075S2

Melatonin-d7

Melatonin-d₇ is the deuterium labeled Melatonin (HY-B0075). Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-14398S

Celecoxib-d7
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ (MK-0663-d₄) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-66005S2

Acetaminophen-d7
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0559S

Nabumetone-d3
Nabumetone-d₃ is the deuterium labeled Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective *COX-2* inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers .

HY-14398S1

Celecoxib-d3
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-66005S4

Acetaminophen-13C2,15N
Acetaminophen- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labeled Acetaminophen . Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM;is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-Y1100S

Cyclopropylmethyl bromide-d4
Cyclopropylmethyl bromide-d₄ is the deuterium labeled Cyclopropylmethyl bromide (HY-Y1100). Cyclopropylmethyl bromide is an intermediate. Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670). Firocoxib (ML 1785713) is a potent, selective, orally active *COX-2* inhibitor .

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .

HY-14670S

Firocoxib-d4
Firocoxib-d₄ (ML 1785713-d₄) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects .

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib . Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood .

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-118139S

Celecoxib-d4
Celecoxib-d₄ is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an?analog?of Celecoxib and with the optimal yield of 75% .

HY-119447S

Mavacoxib-d4
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-66005S3

Acetaminophen-13C6
Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain .

HY-15321S1

Etoricoxib-13C,d3
Etoricoxib- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0335S

Tolfenamic acid-d4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1 .

HY-W777079

Valdecoxib-13C2,15N
Valdecoxib- ¹³C₂, ¹⁵N (SC 65872- ¹³C₂, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Valdecoxib (HY-15762). Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-W745860

Hexahydrocurcumin-d6
Hexahydrocurcumin-d₆ is the deuterium labeled Hexahydrocurcumin (HY-N0929). Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-66005S5

Acetaminophen-d5
Acetaminophen-d₅ is deuterated-labeled Acetaminophen (HY-66005). Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0363S

Nimesulide-d5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties .

HY-W015007S

Metyrosine-13C9,15N,d7
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

HY-17474S

Parecoxib-d3

Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-105028S

Tenidap-d3
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC₅₀ values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties . Tenidap is also a specific SLC26A3 inhibitor .

HY-B0363S1

Nimesulide-13C6
Nimesulide- ¹³C₆ (R805- ¹³C₆) is ¹³C labeled Nimesulide. Nimesulide is a selective *COX-2* inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-17474AS

Parecoxib-d5 sodium

Parecoxib-d₅ sodium is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo .

HY-17474S1

Parecoxib-d5

Parecoxib-d₅ (SC 69124-d₅) is deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-Y1100S1

Cyclopropylmethyl bromide-d3
Cyclopropylmethyl bromide-d₃ is the deuterium labeled Cyclopropylmethyl bromide (HY-Y1100). Cyclopropylmethyl bromide is an intermediate. Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670). Firocoxib (ML 1785713) is a potent, selective, orally active *COX-2* inhibitor .

HY-114200S

Imrecoxib-d7
Imrecoxib-d₇ (BAP-909-d₇) is the deuterium labeled Imrecoxib (HY-114200). Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC₅₀ value of 18 nM, it also inhibits COX1- activity with an IC₅₀ value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect .

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	COX	Inflammation/Immunology
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib SC 58635	COX	Inflammation/Immunology
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

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Selective COX-2 inhibitor

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