EGFR/VEGFR2-IN-11
EGFR/VEGFR2-IN-11 is an EGFR/VEGFR2 inhibitor with IC50 values of 0.62 μM (human EGFR), 2.26 μM (human VEGFR-2), 17.38 μM (human COX-2), and 19.31 μM (human tubulin). EGFR/VEGFR2-IN-11 inhibits COX-2 activity and tubulin polymerization. EGFR/VEGFR2-IN-11 induces cell cycle arrest and apoptosis. EGFR/VEGFR2-IN-11 exerts selective and antiproliferative activity against human cancer cells. EGFR/VEGFR2-IN-11 can be used for the research of colon carcinoma, breast carcinoma, leukemia, lymphoma, glioblastoma.
For research use only. We do not sell to patients.
- Formula: C28H24N2O6
- Molecular Weight:484.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EGFR 0.62 μM (IC50) |
VEGFR2 2.26 μM (IC50) |
COX-2 17.38 μM (IC50) |
EGFR/VEGFR2-IN-11 (compound 9) potently inhibits EGFR (IC50 0.62 μM), VEGFR-2 (IC50 2.26 μM), COX-2 (IC50 17.38 μM), and tubulin polymerization (IC50 19.31 μM)[1].
EGFR/VEGFR2-IN-11 (48 h) potently inhibits proliferation of U937, Jurkat, HCT-116, MCF-7, and U87 human cancer cell lines with IC50 values ranging from 1.48 to 13.19 μM, and shows no significant toxicity to normal F180 fibroblasts (IC50 > 50 μM)[1].
EGFR/VEGFR2-IN-11 induces cell cycle arrest at the G0/G1 phase in U937 human lymphoma cells[1].
EGFR/VEGFR2-IN-11 strongly stimulates apoptosis in U937 human lymphoma cells, increasing total apoptotic cells to 29.65%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 484.50
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Formula C28H24N2O6
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SMILES
OC1=C(C(/C=C/C2=CC=C(/C=C/C(C3=CC(NC(C)=O)=CC=C3O)=O)C=C2)=O)C=C(NC(C)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/VEGFR2-IN-11 Related Classifications
HY-181766 Related Classifications
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