COX-1-IN-1
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC50s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC50/COX-1 IC50) is 217. COX-1-IN-1 inhibits platelet aggregation.
For research use only. We do not sell to patients.
- CAS No.: 1369503-03-6
- Formula: C20H21NO3
- Molecular Weight:323.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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COX-1 0.23 μM (IC50) |
COX-2 50 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
1 μM
Compound: 15a; MSA19
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Antiplatelet activity in human platelets assessed as inhibition of arachidonic acid-induced platelet aggregation measured after 2 mins by turbidimetric analysis
Antiplatelet activity in human platelets assessed as inhibition of arachidonic acid-induced platelet aggregation measured after 2 mins by turbidimetric analysis
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[PMID: 38219659] |
COX-1-IN-1 inhibits arachidonic acid (AA) induced platelet aggregation with IC50 of 1 μM. COX-1-IN-1 (100 μM, 3 h) reveals low cytotoxicity for cells and platelets[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero
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Concentration:100 μM
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Incubation Time:3 h
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Result:Revealed platelet and cell viabilities above 90%.
Chemical Information
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CAS No. 1369503-03-6
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Molecular Weight 323.39
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Formula C20H21NO3
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SMILES
CCOC1=CC=C(C2=NOC(C)=C2C3=CC=C(OCC)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)