COX-1-IN-1
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC50s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC50/COX-1 IC50) is 217. COX-1-IN-1 inhibits platelet aggregation.
For research use only. We do not sell to patients.
- CAS No.: 1369503-03-6
- Formula: C20H21NO3
- Molecular Weight:323.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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COX-1 0.23 μM (IC50) |
COX-2 50 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Platelet | IC50 |
1 μM
Compound: 15a; MSA19
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Antiplatelet activity in human platelets assessed as inhibition of arachidonic acid-induced platelet aggregation measured after 2 mins by turbidimetric analysis
Antiplatelet activity in human platelets assessed as inhibition of arachidonic acid-induced platelet aggregation measured after 2 mins by turbidimetric analysis
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[PMID: 38219659] |
In Vitro
COX-1-IN-1 inhibits arachidonic acid (AA) induced platelet aggregation with IC50 of 1 μM. COX-1-IN-1 (100 μM, 3 h) reveals low cytotoxicity for cells and platelets[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Vero
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Concentration:100 μM
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Incubation Time:3 h
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Result:Revealed platelet and cell viabilities above 90%.
Chemical Information
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CAS No. 1369503-03-6
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Molecular Weight 323.39
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Formula C20H21NO3
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SMILES
CCOC1=CC=C(C2=NOC(C)=C2C3=CC=C(OCC)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-1-IN-1 Related Classifications
HY-162167 Related Classifications
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