Dihydroflavokawin B 

Dihydroflavokawin B is a selective COX-1 inhibitor with an IC₅₀ of 1.22 μM. Dihydroflavokawin B weakly inhibits COX-2 and 5-LOX. Dihydroflavokawin B inhibits promastigote forms of Leishmania panamensis and Leishmania braziliensis. Dihydroflavokawin B inhibits rabbit platelet aggregation induced by Arachidonic acid, platelet activating factor, and adenosine diphosphate. Dihydroflavokawin B exhibits in vitro anti-inflammatory activity. Dihydroflavokawin B can be used for the research of leishmaniasis^[1][2].

Dihydroflavokawin B (compound 8) (1.5625-200 μg/mL; 72 h) shows leishmanicidal activity against L. panamensis promastigotes with EC₅₀ values of 19.9 μg/mL and 25.0 μg/mL, cytotoxicity to J774 murine macrophages with an LC₅₀ of 49.02 μg/mL, giving a selectivity index of 2^[1].
Dihydroflavokawin B (compound 6) potently inhibits ovine COX-1 (IC₅₀ = 1.22 μM) but weakly inhibits ovine COX-2 (IC₅₀ = 457 μM) and potato 5-LOX (IC₅₀ = 127 μM)^[2].
Dihydroflavokawin B inhibits Arachidonic acid (HY-109590)-induced rabbit platelet aggregation (IC₅₀ = 43.2 μM) more potently than PAF- or ADP-induced aggregation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

286.33

C₁₇H₁₈O₄

3791-76-2

O=C(C=1C(O)=CC(OC)=CC1OC)CCC=2C=CC=CC2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sánchez-Suárez J, et al. Leishmanicidal and cytotoxic activities of extracts and naturally-occurring compounds from two Lauraceae species. Nat Prod Commun. 2011;6(2):231-234.  [Content Brief]

  [2]. Coy-Barrera ED, et al. In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants. An Acad Bras Cienc. 2011;83(4):1397-1402.  [Content Brief]