Dihydroflavokawin B
Dihydroflavokawin B is a selective COX-1 inhibitor with an IC50 of 1.22 μM. Dihydroflavokawin B weakly inhibits COX-2 and 5-LOX. Dihydroflavokawin B inhibits promastigote forms of Leishmania panamensis and Leishmania braziliensis. Dihydroflavokawin B inhibits rabbit platelet aggregation induced by Arachidonic acid, platelet activating factor, and adenosine diphosphate. Dihydroflavokawin B exhibits in vitro anti-inflammatory activity. Dihydroflavokawin B can be used for the research of leishmaniasis.
For research use only. We do not sell to patients.
- CAS No.: 3791-76-2
- Formula: C17H18O4
- Molecular Weight:286.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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COX-1 1.22 μM (IC50) |
COX-2 457 μM (IC50) |
Dihydroflavokawin B (compound 8) (1.5625-200 μg/mL; 72 h) shows leishmanicidal activity against L. panamensis promastigotes with EC50 values of 19.9 μg/mL and 25.0 μg/mL, cytotoxicity to J774 murine macrophages with an LC50 of 49.02 μg/mL, giving a selectivity index of 2[1].
Dihydroflavokawin B (compound 6) potently inhibits ovine COX-1 (IC50 = 1.22 μM) but weakly inhibits ovine COX-2 (IC50 = 457 μM) and potato 5-LOX (IC50 = 127 μM)[2].
Dihydroflavokawin B inhibits Arachidonic acid (HY-109590)-induced rabbit platelet aggregation (IC50 = 43.2 μM) more potently than PAF- or ADP-induced aggregation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3791-76-2
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Molecular Weight 286.33
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Formula C17H18O4
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SMILES
O=C(C=1C(O)=CC(OC)=CC1OC)CCC=2C=CC=CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sánchez-Suárez J, et al. Leishmanicidal and cytotoxic activities of extracts and naturally-occurring compounds from two Lauraceae species. Nat Prod Commun. 2011;6(2):231-234. [Content Brief]
[2]. Coy-Barrera ED, et al. In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants. An Acad Bras Cienc. 2011;83(4):1397-1402. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydroflavokawin B Related Classifications
HY-W676872 Related Classifications
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