2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase COX
  4. COX-2/5-LOX-IN-6

COX-2/5-LOX-IN-6 (Compound 4c) is a potent and selective 5-LOX (IC50 = 0.10 μM) and COX-2 (IC50: 2.88 μM) inhibitor. COX-2/5-LOX-IN-6 displays potent anticancer activity against ovarian cancer. COX-2/5-LOX-IN-6 would not cause cytotoxic effects in noncancerous cells. COX-2/5-LOX-IN-6 is a potential anti-inflammatory agent.

For research use only. We do not sell to patients.

COX-2/5-LOX-IN-6

COX-2/5-LOX-IN-6 Chemical Structure

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COX-2/5-LOX-IN-6 Related Antibodies

Top Publications Citing Use of Products

View All Lipoxygenase Isoform Specific Products:

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5-LOX 12-LOX 15-LOX

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

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Description

COX-2/5-LOX-IN-6 (Compound 4c) is a potent and selective 5-LOX (IC50 = 0.10 μM) and COX-2 (IC50: 2.88 μM) inhibitor. COX-2/5-LOX-IN-6 displays potent anticancer activity against ovarian cancer. COX-2/5-LOX-IN-6 would not cause cytotoxic effects in noncancerous cells. COX-2/5-LOX-IN-6 is a potential anti-inflammatory agent[1].

IC50 & Target[1]

5-LOX

0.10 μM (IC50)

COX-2

2.88 μM (IC50)

Molecular Weight

517.38

Formula

C25H23FeN3O4S
SMILES

O=S(N)(C1=CC=C(N2C(C3=CC(O)=C(O)C=C3)CC(c4cccc4)=N2)C=C1)=O.[][Fe][].c5cccc5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2/5-LOX-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/5-LOX-IN-6LipoxygenaseCOXLOXCyclooxygenaseovarian canceranticanceranti-inflammatoryInhibitorinhibitorinhibit

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