Indomethacin N-octyl amide
Indomethacin N-octyl amide (Compound 2) is a potent and selective COX-2 inhibitor with an IC50 of 40 nM. Indomethacin N-octyl amide shows >1000-fold selectivity against COX-1 (IC50 of 66 µM).
For research use only. We do not sell to patients.
- CAS No.: 282728-65-8
- Formula: C27H33ClN2O3
- Molecular Weight:469.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
COX-2 0.04 μM (IC50) |
COX-1 66 μM (IC50) |
Chemical Information
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CAS No. 282728-65-8
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Molecular Weight 469.02
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Formula C27H33ClN2O3
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SMILES
O=C(NCCCCCCCC)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indomethacin N-octyl amide Related Classifications
HY-134138 Related Classifications
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