Tenidap (Standard)
Tenidap (CP-66248) (Standard) is the analytical standard of Tenidap (CP-66248) (HY-105028). This product is intended for research and analytical applications. Tenidap (CP-66248) is an orally active cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor. Tenidap exerts anti-inflammatory and chondroprotective effects by downregulating IL-1 receptor expression, reducing the release of pro-inflammatory cytokines, and inhibiting metalloproteinase and acute-phase protein production, while also inhibiting SLC26A3-mediated chloride transport and the pH and membrane potential changes associated with sperm capacitation. Tenidap attenuates carrageenan-induced paw edema and acetic acid-induced writhing, and induces gastric ulcers in a dose-dependent manner, and can be used for research on rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 120210-48-2
- Formula: C14H9ClN2O3S
- Molecular Weight:320.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-105028
TenidapCOX/5-LOX Inhibitor -
HY-13568
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HY-B0253
PiroxicamCOX Inhibitor -
HY-B0138
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HY-111140
YS121mPGES-1/5-LOX Inhibitor -
HY-B0634
AceclofenacNSAID -
HY-B0578A
Loxoprofen sodiumAnti-Inflammatory Agent -
HY-B0138R
Ketorolac tromethamine salt (Standard)COX Inhibitor -
HY-115866
COX-2-IN-6COX Inhibitor -
HY-13568R
Benoxaprofen (Standard)Anti-inflammatory/Antipyretic Compound -
HY-B0253R
Piroxicam (Standard)COX Inhibitor -
HY-126898
5-LO/mPGES1-IN-15-LO/mPGES-1 Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 120210-48-2
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Molecular Weight 320.75
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Formula C14H9ClN2O3S
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SMILES
O/C(C1=CC=CS1)=C2C3=C(C=CC(Cl)=C3)N(C(N)=O)C/2=O
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Synonyms
CP-66248 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Breedveld F, et al. Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis. Scandinavian journal of rheumatology. Supplement. 1994;100:31-44. [Content Brief]
[5]. Lai Y, et al. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorganic & medicinal chemistry letters. 2010 Dec 15;20(24):7349-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tenidap (Standard) Related Classifications
HY-105028R Related Classifications
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Keywords
- Tenidap (Standard)
- 120210-48-2
- CP-66248 (Standard)
- Reference Standards
- COX
- Lipoxygenase
- Chloride Channel
- Interleukin Related
- Cyclooxygenase
- LOX
- Cl− Channels
- IL
- 5-lipoxygenase
- IL-1 receptor
- bone resorption
- cartilage degradation
- cyclooxygenase
- glycosaminoglycan synthesis
- leucocyte-endothelial adhesion
- metalloprotease
- monocyte differentiation
- proinflammatory cytokine
- Inhibitor
- inhibitor
- inhibit