Desmethyl etoricoxib

Cat. No.: HY-138101 Purity: 99.64%: Data Sheet
COA
Handling Instructions
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Desmethyl etoricoxib (example 21) is a selective COX-2 inhibitor with an IC₅₀ of 1 μM in whole blood. Desmethyl etoricoxib inhibits COX-1 with an IC₅₀ of 16 μM in U937 cells. Desmethyl etoricoxib has anti-inflammatory effects.

For research use only. We do not sell to patients.

Desmethyl etoricoxib Chemical Structure

CAS No. : 202409-31-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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COX COX-1 COX-2 COX-3

Biological Activity
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Description

IC₅₀ & Target^[1]

COX-2

1 μM (IC₅₀)

COX-1

16 μM (IC₅₀)

Molecular Weight

344.82

Formula

C₁₇H₁₃ClN₂O₂S

CAS No.

202409-31-2

Appearance

Solid

SMILES

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=CN=C3)C=C1)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (362.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9001 mL	14.5003 mL	29.0006 mL
5 mM	0.5800 mL	2.9001 mL	5.8001 mL
10 mM	0.2900 mL	1.4500 mL	2.9001 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.64%

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COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Daniel Dube, et al. Substituted pyridines as selective cyclooxygenase-2 inhibitors. WO9803484A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9001 mL	14.5003 mL	29.0006 mL	72.5016 mL
	5 mM	0.5800 mL	2.9001 mL	5.8001 mL	14.5003 mL
	10 mM	0.2900 mL	1.4500 mL	2.9001 mL	7.2502 mL
	15 mM	0.1933 mL	0.9667 mL	1.9334 mL	4.8334 mL
	20 mM	0.1450 mL	0.7250 mL	1.4500 mL	3.6251 mL
	25 mM	0.1160 mL	0.5800 mL	1.1600 mL	2.9001 mL
	30 mM	0.0967 mL	0.4833 mL	0.9667 mL	2.4167 mL
	40 mM	0.0725 mL	0.3625 mL	0.7250 mL	1.8125 mL
	50 mM	0.0580 mL	0.2900 mL	0.5800 mL	1.4500 mL
	60 mM	0.0483 mL	0.2417 mL	0.4833 mL	1.2084 mL
	80 mM	0.0363 mL	0.1813 mL	0.3625 mL	0.9063 mL
	100 mM	0.0290 mL	0.1450 mL	0.2900 mL	0.7250 mL