1. Immunology/Inflammation
  2. COX
  3. COX-2-IN-29

COX-2-IN-29 

Cat. No.: HY-150721
Handling Instructions

COX-2-IN-29 (Compound 15b) is a selective and orally active COX-2 inhibitor with an IC50 of 0.005 μM.

For research use only. We do not sell to patients.

COX-2-IN-29 Chemical Structure

COX-2-IN-29 Chemical Structure

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Description

COX-2-IN-29 (Compound 15b) is a selective and orally active COX-2 inhibitor with an IC50 of 0.005 μM[1].

IC50 & Target

COX-2

0.005 μM (IC50)

COX-1

> 10 μM (IC50)

In Vitro

COX-2-IN-29 (Compound 15b) shows metabolic stability with intrinsic clearance value of 39.9 and 40.3 µL/min/mg protein in mouse and human liver microsomes, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

COX-2-IN-29 (Compound 15b) (10 and 20 mg/kg; p.o.; once) shows antinociceptive activity at 20 mg/kg, and shows anti-inflammatory and anti-edema activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD1 albino mice (23 – 25 g) or male Sprague–Dawley rats weighing approximately 200 – 250 g[1]
Dosage: 10 and 20 mg/kg
Administration: PO, once
Result: Induced a reduction of the number of writhes in a statistically significant manner at the minimum dose of 20 mg/kg, while didn’t show any antinociceptive efficacy at 10 mg/kg. Showed a good activity against carrageenan-induced hyperalgesia 30 min after administration, disappearing completely at 1 h after treatment. A very good activity was demonstrated against carrageenan induced edema in the rat paw.
Molecular Weight

494.56

Formula

C22H23FN2O6S2

SMILES

O=[N+]([O-])OCCS(CCC1=C(C)N(C2=CC=C(F)C=C2)C(C3=CC=C(S(=O)(C)=O)C=C3)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
COX-2-IN-29
Cat. No.:
HY-150721
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