2. Immunology/Inflammation Anti-infection NF-κB Metabolic Enzyme/Protease
  3. COX Bacterial Reactive Oxygen Species (ROS)
  4. COX-2-IN-65

COX-2-IN-65 is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 10.24 μM. COX-2-IN-65 inhibits Staphylococcus aureus and Escherichia coli growth. COX-2-IN-65 scavenges reactive oxygen species (ROS). COX-2-IN-65 can be used for the researches of bacterial infections and inflammation.

For research use only. We do not sell to patients.

COX-2-IN-65

COX-2-IN-65 Chemical Structure

CAS No. : 1408337-43-8

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COX-2-IN-65 Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

COX-2-IN-65 is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 10.24 μM. COX-2-IN-65 inhibits Staphylococcus aureus and Escherichia coli growth. COX-2-IN-65 scavenges reactive oxygen species (ROS). COX-2-IN-65 can be used for the researches of bacterial infections and inflammation[1].

IC50 & Target[1]

COX-2

10.24 μM (IC50)

In Vitro

COX-2-IN-65 (Compound 4h) selectively inhibits recombinant human COX-2 with an IC50 of 10.24 μM and a selectivity index of 3.09[1].
COX-2-IN-65 inhibits 30% of Staphylococcus aureus growth and 90% of Escherichia coli growth[1].
COX-2-IN-65 (50-100 μg/mL) shows ROS-scavenging capacity (37-61%)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-65 Related Antibodies
Molecular Weight

327.76

Formula

C18H14ClNO3
CAS No.
SMILES

CCOC(C1=C2N(C(C(C3=CC=CC=C3)=O)=C1)C=CC(Cl)=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-65 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-651408337-43-8COXBacterialReactive Oxygen Species (ROS)CyclooxygenaseEscherichia colireactive oxygen speciesStaphylococcus aureusCOX-1cyclooxygenase-2inflammatory disordersdihydrofolate reductaseCOX-2ROSInhibitorinhibitorinhibit

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