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Results for "

TREM2 agonist-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TREM receptor (25) 5-HT Receptor (13) ADC Payload (1) Adenosine Receptor (6) Adiponectin Receptor (1) Adrenergic Receptor (6) Akt (3) Amino acid Transporter (1) Amyloid-β (2) Apelin Receptor (APJ) (1) Apoptosis (5) Arginase (1) Arrestin (1) Aryl Hydrocarbon Receptor (1) ATP Synthase (3) Autophagy (4) Biochemical Assay Reagents (1) Bombesin Receptor (1) Calcium Channel (1) Cannabinoid Receptor (7) CD20 (1) Cholecystokinin Receptor (2) Dopamine Receptor (4) Drug Derivative (1) Drug Intermediate (2) Drug Isomer (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (1) Environmental Pollutants (1) Ephrin Receptor (1) ERK (1) Estrogen Receptor/ERR (2) Formyl Peptide Receptor (FPR) (1) Free Fatty Acid Receptor (3) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) GABA Receptor (2) GCGR (2) GHSR (1) GLP Receptor (1) Glucocorticoid Receptor (2) GPR109A (2) GPR119 (1) GPR139 (1) GPR35 (1) GPR6 (1) GPR84 (1) GPR88 (1) Guanylate Cyclase (1) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (4) Hydroxycarboxylic Acid Receptor (HCAR) (1) iGluR (1) IKZF Family (1) Influenza Virus (2) Integrin (1) Interleukin Related (6) Isotope-Labeled Compounds (5) Keap1-Nrf2 (1) LPL Receptor (3) LXR (2) mAChR (4) Mas-related G-protein-coupled Receptor (MRGPR) (1) Melanocortin Receptor (3) mGluR (2) Mitochondrial Metabolism (1) MyD88 (1) nAChR (1) Neuropeptide Y Receptor (1) NF-κB (7) NO Synthase (1) NOD-like Receptor (NLR) (2) Nuclear Hormone Receptor 4A/NR4A (2) Opioid Receptor (6) Orexin Receptor (OX Receptor) (1) Orphan GPCR (2) Orphan Nuclear Receptor (3) P2X Receptor (1) p38 MAPK (3) PI3K (1) Piezo Channel (1) PPAR (6) Prostaglandin Receptor (5) Proteasome (4) PTHR (1) Radionuclide-Drug Conjugates (RDCs) (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (7) Reverse Transcriptase (2) ROR (4) RXFP Receptor (3) Ser/Thr Kinase (1) Serotonin Transporter (2) Sigma Receptor (2) Small Interfering RNA (siRNA) (3) Somatostatin Receptor (1) Syk (4) Taste Receptor (1) TGF-β Receptor (1) Thyroid Hormone Receptor (4) TNF Receptor (2) Toll-like Receptor (TLR) (5) Trace Amine-associated Receptor (TAAR) (1) Transmembrane Glycoprotein (1) TRP Channel (5) VD/VDR (2) Wnt (1) Zinc Finger Protein (1) β-catenin (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (12) Endocrinology (9) Infection (7) Inflammation/Immunology (53) Metabolic Disease (41) Neurological Disease (69)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (1) Phospholipids (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

187

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Targets Recommended: TREM receptor

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-P10136

IA9 2 Publications Verification human TREM-2 182-190	TREM receptor	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant *TREM-2* inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research ^[2].

HY-175510

TREM2 agonist-5	TREM receptor	Neurological Disease
TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a K_d of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease .

HY-P991220

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable *TREM2* modulator. AL002 binds to *TREM2* on the surface of microglia, promotes *TREM2* clustering and the formation of the *TREM2*-DAP12 complex, activates the *TREM2* signaling pathway and PI3K cascade, and induces *TREM2* internalization and degradation. AL002 is applicable to research related to Alzheimer's disease ^[2].

HY-174378

TREM2 agonist-4	TREM receptor	Neurological Disease
TREM2 agonist-4 (Compound 4a) is a *TREM2* agonist with a K_d value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of *TREM2* and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-160421

TREM2-IN-1	Apoptosis	Inflammation/Immunology Cancer
TREM2-IN-1 (OPA) is a *TREM2* inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 ⁺ and CX₃CR1 ⁺ immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .

HY-174369

TREM2 agonist-3	TREM receptor Syk	Neurological Disease
TREM2 agonist-3 (Compound 4i) is a *TREM2* agonist with a K_D value of 19.0 µM. The K_D value of TREM2 agonist-3 for TREM1 is 39.8 µM. TREM2 agonist-3 induces an increase in phosphorylated SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases associated with TREM2 dysfunction .

HY-147105

LRH-1 agonist-2	Orphan Nuclear Receptor Interleukin Related	Inflammation/Immunology
LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC₅₀ of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease .

HY-P990043

Iluzanebart VGL101	Ser/Thr Kinase TREM receptor	Inflammation/Immunology
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .

HY-P991621

EOS006215 EOS-215	TREM receptor	Cancer
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting *TREM-2. EOS006215 competes with TREM2* ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .

HY-P991442

DNL-919 (Human IgG1) TAK-920	TREM receptor	Neurological Disease
DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting *TREM-2*. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991734

VHB937	TREM receptor Syk Calcium Channel	Neurological Disease Inflammation/Immunology
VHB937 is a potent and selective *TREM2* agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research .

HY-P10136A

IA9 TFA 2 Publications Verification human TREM-2 182-190 TFA	TREM receptor	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant *TREM-2* inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research ^[2].

HY-153265

TAS2R14 agonist-2	Taste Receptor	Inflammation/Immunology
TAS2R14 agonist-2 (compound 28.1) is a potent and selective *TAS2R14* agonist with an EC₅₀ value of 72 nM. TAS2R14 agonist-2 reveals marked selectivity over a panel of 24 non-bitter taste human G protein-coupled receptors. TAS2R14 agonist-2 can be used for the studies of asthma or chronic obstructive pulmonary disease .

HY-148436

*Glucocorticoid receptor agonist-2* Ala-Ala-Mal**	Drug-Linker Conjugates for ADC	Inflammation/Immunology
Glucocorticoid receptor agonist-2 Ala-Ala-Mal (compound 79) can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference for ABBV-3373 .

HY-175287

α5β1 integrin agonist-2	Integrin	Cancer
α5β1 integrin agonist-2 (Compound 2) is a selective α5β1 integrin agonist (EC₅₀ = 45.98 nM). α5β1 integrin agonist-2 induces integrin activation. α5β1 integrin agonist-2 is applicable to the research of leukemia .

HY-143613

THR-β agonist 2	Thyroid Hormone Receptor	Metabolic Disease
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3) .

HY-148435

Glucocorticoid receptor agonist-2	Glucocorticoid Receptor ADC Payload	Inflammation/Immunology
Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC₅₀ value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373 .

HY-178324

T2M-010	TREM receptor Syk	Neurological Disease Inflammation/Immunology
T2M-010 is a potent, brain-penetrant *TREM2* agonist (K_d = 0.83 μM). T2M-010 activates receptor-proximal signaling, inducing SYK phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimer’s disease (AD) .

HY-P990651

PY314	TREM receptor	Cancer
PY314 is a humanized antibody targeting *TREM2. PY314 binds TREM2* on tumor-associated macrophages, depletes *TREM2*-high tumor-associated macrophages, reduces pro-tumorigenic M2 macrophage infiltration, increases CD8 ⁺ T cell, NK cell, and M1 macrophage infiltration, creates a proinflammatory tumor microenvironment, and promotes antitumor immune responseS. PY314 can be used for the research of platinum-resistant ovarian cancer, advanced solid tumors, breast cancer, and advanced refractory solid tumors ^[2] .

HY-RS15003

TREM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TREM2 Human Pre-designed siRNA Set A contains three designed siRNAs for TREM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TREM2 Human Pre-designed siRNA Set A TREM2 Human Pre-designed siRNA Set A

HY-RS16526

Trem2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trem2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trem2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trem2 Mouse Pre-designed siRNA Set A Trem2 Mouse Pre-designed siRNA Set A

HY-144339

AhR agonist 2 1 Publications Verification	Aryl Hydrocarbon Receptor	Others
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC₅₀ of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis .

HY-W677684

Nurr1 agonist 2	Nuclear Hormone Receptor 4A/NR4A	Others
Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC₅₀: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a K_d value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression .

HY-P991174

*Anti-TREM2* Antibody (AL2p-58)**	TREM receptor	Inflammation/Immunology
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody targeting *TREM2. Anti-TREM2* Antibody (AL2p-58) can be used for the research of neuroinflammation. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-100469

LXRβ agonist-2	LXR	Inflammation/Immunology
LXRβ agonist-2 is an orally active and selective LXRβ agonist. LXRβ agonist-2 increases high-density lipoprotein cholesterol levels without elevating plasma triglyceride levels. LXRβ agonist-2 decreases lipid accumulation area in the aortic arch. LXRβ agonist-2 can be used for the research of atherosclerosis .

HY-158203

BMP agonist 2	TGF-β Receptor	Others
BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine. BMP agonist 2 promotes bone tissue production by increasing the proportion and activity of osteoblasts. BMP agonist 2 promotes osteoblast proliferation and differentiation through the *BMP2-ATF4* signaling axis, in which ATF4 is a transcription factor closely related to osteoblast differentiation and bone formation. BMP agonist 2 can be used in the study of senile osteoporosis (SOP) .

HY-155318A

GPR3 agonist-2	Orphan GPCR	Endocrinology
GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC₅₀of 260 nM .

HY-142699

SSTR4 agonist 2	Somatostatin Receptor	Inflammation/Immunology
SSTR4 agonist 2 is a potent agonist of somatostatin receptor subtype 4 (SSTR4). SSTR4 pathway inhibits nociceptive and inflammatory processes. SSTR4 agonist 2 has the potential for the research of medical disorders related to SSTR4 (extracted from patent WO2014184275A1, compound 107) .

HY-144604

FPR2 agonist 2	Formyl Peptide Receptor (FPR)	Infection Neurological Disease
FPR2 agonist 2 is a potent and CNS-penetrant *FPR2* agonist with an EC₅₀ of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity .

HY-173556

GPR84 agonist-2	GPR84	Inflammation/Immunology
GPR84 agonist-2 is a selective GPR84 agonist with no activity at free fatty acid receptors. GPR84 agonist-2 enhances GPR84-mediated signaling above basal levels and potentiates agonist-induced GPR84 activation. GPR84 agonist‑2 can be used for research on GPR84-related physiological mechanisms .

HY-149651

GPR139 agonist-2	GPR139	Neurological Disease
GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC₅₀ of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research .

HY-149764

Aβ42 agonist-2	Amyloid-β	Neurological Disease
Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

HY-145364

Ghrelin receptor full agonist-2	GHSR	Metabolic Disease
Ghrelin receptor full agonist-2 (compound 12j) is a highly potent Ghrelin receptor full agonist.

HY-145841

5-HT2A receptor agonist-2	5-HT Receptor	Cardiovascular Disease
5-HT2A receptor agonist-2 is a highly potent serotonin 5-HT2 receptor agonists. 5-HT2A receptor agonist-2 inspires 5-HT_2A, 5-HT_2B, and 5-HT_2C with EC₅₀ values of 1.7, 0.58, and 0.50 nM, respectively .

HY-148525

PF-4348235 β2AR/M-receptor agonist-2	mAChR Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC₅₀ value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a K_i value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-RS22957

Trem2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trem2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trem2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trem2 Rat Pre-designed siRNA Set A Trem2 Rat Pre-designed siRNA Set A

HY-178982

Apelin agonist 2	Apelin Receptor (APJ)	Metabolic Disease
Apelin agonist 2 (Compound 35) is an orally active APLNR agonist. Apelin agonist 2 can significantly inhibit the accumulation of cAMP (EC₅₀ = 10 nM). Apelin agonist 2 exhibits a significant improvement in glucose tolerance. Apelin agonist 2 can be used to study metabolic diseases such as diabetes .

HY-139177

PPARα agonist 2	PPAR	Cardiovascular Disease
PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC₅₀ of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research .

HY-47823

GPCR agonist-2	GPR109A	Metabolic Disease
GPCR agonist-2 (Compound 5j) is a GPCR GPR109b (HM74) agonist, with a pEC₅₀ value of 6.51. GPCR agonist-2 can be used for research of lipid disorders .

HY-151107

CBR Agonist-2	Cannabinoid Receptor	Neurological Disease
CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC₅₀ and a K_i of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system .

HY-182756

TREM2 modulator-1	TREM receptor	Neurological Disease
TREM2 modulator-1 is a *TREM2* modulator with an EC₅₀ categorized as A and Emax of ++, and can be found in relevant research contexts. TREM2 modulator-1 modulates Triggering Receptor Expressed on Myeloid Cells 2. TREM2 modulator-1 can be used for the research of neurodegenerative diseases .

HY-P991754

*Anti-Mouse TREM2* Antibody (178)**	TREM receptor	Inflammation/Immunology
Anti-Mouse TREM2 Antibody (178) reacts with mouse TREM-2 that inhibits TREM-2 both in vivo and in vitro. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679) .

HY-P10220

NOTA-COG1410	Radionuclide-Drug Conjugates (RDCs) TREM receptor	Cancer
NOTA-COG1410 forms triggering receptor expressed on myeloid cells 2 (TREM2) targeting ligand. NOTA-COG1410 is capable of being labelled with ⁶⁸Gallium ( ⁶⁸Ga) for discovery and diagnosis of digestive system tumors through positron emission tomography/computed tomography (PET/CT). NOTA-COG1410 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .

HY-147500

TRβ agonist 2	Thyroid Hormone Receptor	Metabolic Disease
TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics .

HY-146288

LXR agonist 2	LXR	Metabolic Disease
LXR agonist 2 (compound 18rr) is a potent LXR (liver X receptor) agonist. LXR agonist 2 can stabilize NCOA1 (co-activator), leading to LXR agonism .

HY-176504

Adenosine receptor agonist 2	Adenosine Receptor	Cardiovascular Disease
Adenosine receptor agonist 2 (Compound 10) is an adenosine A_2B receptor (A_2BR) agonist with an EC₅₀ of 0.38 nM. Adenosine receptor agonist 2 significantly inhibits the accumulation of cAMP and calcium. Adenosine receptor agonist 2 can be used for cardioprotection research .

HY-146141

EphA2 agonist 2	Ephrin Receptor	Cancer
EphA2 agonist 2 (Lead compound) is a selective *EphA2* agonist with antitumor activities. EphA2 agonist 2 can cross the BBB .

HY-W010270A

Aurothiomalate disodium	TRP Channel NF-κB NO Synthase TREM receptor Arginase	Metabolic Disease Inflammation/Immunology
Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of *TREM-2* and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis ^[2].

HY-141454

TLR8 agonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR8 agonist 2 is a potent and selective TLR8 agonist with an EC₅₀ of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC₅₀ of 33.33 μM) .

HY-175490

RORγ inverse agonist 2	ROR	Inflammation/Immunology
RORγ inverse agonist 2 (Compound 15) is a potent inverse agonist of the retinoic acid receptor-related orphan receptor RORγ, with IC₅₀ values of 0.4 and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. RORγ inverse agonist 2 is useful in the study of autoimmune diseases .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N0166

Gramine 4 Publications Verification Donaxine	Infection Alkaloids Structural Classification Classification of Application Fields Gramineae Metabolic Disease Plants Disease Research Fields Arundo donax Linn. Endocrinology Indole Alkaloids Source Classification	Adiponectin Receptor Reverse Transcriptase
Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse **β2-Adrenergic receptor (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-N0808

Camphor 3 Publications Verification (±)-Camphor	Infection Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Plants Lauraceae Cinnamomum camphora Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants TRP Channel Influenza Virus
Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .

HY-N0808R

Camphor (Standard) (±)-Camphor (Standard)	Structural Classification Other Monoterpenes Terpenoids Plants Lauraceae Cinnamomum camphora Source Classification	Reference Standards TRP Channel Influenza Virus
Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .

HY-N9164

Hecubine	Apocynaceae Structural Classification Alkaloids Piperidine Alkaloids Tabernaemontana bufalina Lour. Plants Source Classification	TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)
Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates *TREM2* expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the *Nrf2/HO-1* pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases .

HY-W013788

2-Palmitoylglycerol 2-Palm-Gl	Natural Products Microorganisms Endogenous metabolite Source Classification	Cannabinoid Receptor
2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 .

HY-N0166R

Gramine (Standard) 4 Publications Verification Donaxine (Standard)	Infection Alkaloids Classification of Application Fields Gramineae Metabolic Disease Plants Disease Research Fields Arundo donax Linn. Endocrinology Source Classification	Reference Standards Adrenergic Receptor Reverse Transcriptase
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse **β2-Adrenergic receptor (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-W013788R

2-Palmitoylglycerol (Standard) 2-Palm-Gl (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Cannabinoid Receptor
2-Palmitoylglycerol (Standard) is the analytical standard of 2-Palmitoylglycerol. This product is intended for research and analytical applications. 2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 .

Cat. No.	상품명	Chemical Structure

HY-10227S

Bortezomib-d8

Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) ^[2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-10002S1

Calcitriol-d3
Calcitriol-d₃ is the deuterium labeled Calcitriol . Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist .

HY-B0716S2

Urapidil-d4
Urapidil-d₄ is the deuterium labeled Urapidil . Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist .

HY-W017540S

Cyclocreatine-13C3

Cyclocreatine- ¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer ^[2] .

HY-Y1176S

Isonipecotic acid-d9
Isonipecotic acid-d₉ is the deuterium labeled Isonipecotic acid . Isonipecotic acid is a GABAA receptor partial agonist .

HY-B1161S

Methoprene-d7
Methoprene-d₇ is the deuterium labeled Methoprene . Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-153660S

Bivamelagon-d8
Bivamelagon-d₈ (MC-4R Agonist 2-d₈) is the deuterium labeled Bivamelagon (HY-153660). Bivamelagon (MC-4R Agonist 2) is an orally active MC4R agonist with EC₅₀ values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a K_i of 65 nM. Bivamelagon can be used for the research of diseases such as obesity and diabetes .

Targets Recommended: TREM receptor

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-10227G

Bortezomib PS-341; LDP-341; NSC 681239	Proteasome NF-κB Apoptosis Autophagy TREM receptor	Cancer
Bortezomib (GMP) (PS-341 (GMP)) is Bortezomib (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) ^[2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

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