5-HT1AR agonist 2
5-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM). 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM). 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice.
For research use only. We do not sell to patients.
- Formula: C31H31N5O3
- Molecular Weight:521.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT1A Receptor 10 nM (Ki) |
5-HT1A Receptor |
5-HT6 Receptor |
5-HT6 Receptor 192 nM (Ki) |
D2 Receptor 23 nM (Ki) |
5-HT1AR agonist 2 (10 μM) exhibits high stability in human microsomes, with intrinsic clearance values lower than 115.5 μL/min/mg and t1/2 higher than 209 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice (29-42 g)[1]
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Dosage:5, 20 mg/kg.
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Administration:Intraperitoneal injection (i.p.).
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Result:Induced hypothermia in mice at a dose of 20 mg/kg.
Chemical Information
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Molecular Weight 521.61
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Formula C31H31N5O3
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SMILES
N#CC1=CC2=C(NC=C2C3=CCN(CCCCN4C(C(C5=CNC6=C5C=C(OC)C=C6)CC4=O)=O)CC3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-HT1AR agonist 2 Related Classifications
HY-169394 Related Classifications
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