5-HT1AR agonist 2
5-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM). 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM). 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice.
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- Formule: C31H31N5O3
- Masse moléculaire:521.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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5-HT1A Receptor 10 nM (Ki) |
5-HT1A Receptor |
5-HT6 Receptor |
5-HT6 Receptor 192 nM (Ki) |
D2 Receptor 23 nM (Ki) |
5-HT1AR agonist 2 (10 μM) exhibits high stability in human microsomes, with intrinsic clearance values lower than 115.5 μL/min/mg and t1/2 higher than 209 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice (29-42 g)[1]
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Dosage:5, 20 mg/kg.
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Administration:Intraperitoneal injection (i.p.).
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Result:Induced hypothermia in mice at a dose of 20 mg/kg.
Chemical Information
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Masse moléculaire 521.61
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Formule C31H31N5O3
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SMILES
N#CC1=CC2=C(NC=C2C3=CCN(CCCCN4C(C(C5=CNC6=C5C=C(OC)C=C6)CC4=O)=O)CC3)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)