Anti-TREM2 Antibody (AL2p-58) 

Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody targeting TREM2. Anti-TREM2 Antibody (AL2p-58) can be used for the research of neuroinflammation. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

TREM2, is a receptor expressed on microglia and involved in the regulation of inflammatory processes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

54209  [NCBI]

Q9NZC2-1

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

147.2 kDa

Liquid

Colorless to light yellow

[Anti-TREM2 Antibody (AL2p-58)]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Flow Cytometry analysis of THP-1 cells labelling TREM2 (red) with Anti-TREM2 Antibody (HY-P991174). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

• [1]. Bettina van Lengerich, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023 Mar;26(3):416-429.  [Content Brief]