2. Immunology/Inflammation
  3. TREM receptor
  4. TREM2 agonist-4

TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease.

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TREM2 agonist-4

TREM2 agonist-4 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

TREM2 agonist-4 Related Antibodies

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Description

TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1].

IC50 & Target[1]

TREM-2

45.9 μM (Kd)

Molecular Weight

468.65

Formula

C27H36N2O3S
Appearance

Solid

Color

off-white

SMILES

C=C1CC(C1)C(NC2=CC(C(NC)=O)=CC(C3=C(CCCCCCCC)C=CS3)=C2OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (213.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1338 mL 10.6689 mL 21.3379 mL
5 mM 0.4268 mL 2.1338 mL 4.2676 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1338 mL 10.6689 mL 21.3379 mL 53.3447 mL
5 mM 0.4268 mL 2.1338 mL 4.2676 mL 10.6689 mL
10 mM 0.2134 mL 1.0669 mL 2.1338 mL 5.3345 mL
15 mM 0.1423 mL 0.7113 mL 1.4225 mL 3.5563 mL
20 mM 0.1067 mL 0.5334 mL 1.0669 mL 2.6672 mL
25 mM 0.0854 mL 0.4268 mL 0.8535 mL 2.1338 mL
30 mM 0.0711 mL 0.3556 mL 0.7113 mL 1.7782 mL
40 mM 0.0533 mL 0.2667 mL 0.5334 mL 1.3336 mL
50 mM 0.0427 mL 0.2134 mL 0.4268 mL 1.0669 mL
60 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.8891 mL
80 mM 0.0267 mL 0.1334 mL 0.2667 mL 0.6668 mL
100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.5334 mL
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TREM2 agonist-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TREM2 agonist-4TREM receptorTriggering receptors expressed on myeloid cellsHEK293BV2ADInhibitorinhibitorinhibit

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