TREM2 agonist-4
Based on 1 Customer Validation
TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 99.81%
- Formula: C27H36N2O3S
- Molecular Weight:468.65
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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TREM-2 45.9 μM (Kd) |
Chemical Information
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Appearance Solid
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Molecular Weight 468.65
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Formula C27H36N2O3S
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Color off-white
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SMILES
C=C1CC(C1)C(NC2=CC(C(NC)=O)=CC(C3=C(CCCCCCCC)C=CS3)=C2OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (213.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1338 mL | 10.6689 mL | 21.3379 mL | 53.3447 mL |
| 5 mM | 0.4268 mL | 2.1338 mL | 4.2676 mL | 10.6689 mL | |
| 10 mM | 0.2134 mL | 1.0669 mL | 2.1338 mL | 5.3345 mL | |
| 15 mM | 0.1423 mL | 0.7113 mL | 1.4225 mL | 3.5563 mL | |
| 20 mM | 0.1067 mL | 0.5334 mL | 1.0669 mL | 2.6672 mL | |
| 25 mM | 0.0854 mL | 0.4268 mL | 0.8535 mL | 2.1338 mL | |
| 30 mM | 0.0711 mL | 0.3556 mL | 0.7113 mL | 1.7782 mL | |
| 40 mM | 0.0533 mL | 0.2667 mL | 0.5334 mL | 1.3336 mL | |
| 50 mM | 0.0427 mL | 0.2134 mL | 0.4268 mL | 1.0669 mL | |
| 60 mM | 0.0356 mL | 0.1778 mL | 0.3556 mL | 0.8891 mL | |
| 80 mM | 0.0267 mL | 0.1334 mL | 0.2667 mL | 0.6668 mL | |
| 100 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5334 mL |
TREM2 agonist-4 Related Classifications
HY-174378 Related Classifications
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