2. Immunology/Inflammation
  3. TREM receptor
  4. EOS006215

EOS006215  (Synonyms: EOS-215)

Cat. No.: HY-P991621 Purity: 98.47%
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EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer.

For research use only. We do not sell to patients.

EOS006215

EOS006215 Chemical Structure

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EOS006215 Related Antibodies

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Description

EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

TREM-2

 

In Vitro

EOS006215 competes with phosphatidylserine and low density lipoprotein for binding to TREM2, and blocks TREM2 multimerization necessary for downstream signaling[1].
EOS006215 potently inhibits efferocytosis by macrophages, a pathway linked to pro-tumoral macrophage functions, lipid associated macrophage development, and metastatic niche formation[1].
EOS006215 reprograms the transcriptomic profile of monocyte-derived macrophages, enriching gene sets linked to metabolism and immune response regulation, and increases macrophage secretion of pro-inflammatory markers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EOS006215 Related Antibodies
In Vivo

EOS006215 reduces metastasis burden in the orthotopic 4T1 triple negative breast cancer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

54209  [NCBI]

Accession

Q9NZC2-1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

146.57 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

N/A
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EOS006215 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EOS006215EOS-215EOS 006215EOS-006215EOS215EOS 215TREM receptorTriggering receptors expressed on myeloid cellsTREM2colorectal cancerlipid associated macrophagemousemetastatic nichecynomolgustriple negative breast cancermonocyte-derived macrophageshumanefferocytosisInhibitorinhibitorinhibit

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