EOS006215
Based on 1 Customer Validation
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 98.47%
- Molecular Weight:146.57 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
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TREM-2 |
EOS006215 competes with phosphatidylserine and low density lipoprotein for binding to TREM2, and blocks TREM2 multimerization necessary for downstream signaling[1].
EOS006215 potently inhibits efferocytosis by macrophages, a pathway linked to pro-tumoral macrophage functions, lipid associated macrophage development, and metastatic niche formation[1].
EOS006215 reprograms the transcriptomic profile of monocyte-derived macrophages, enriching gene sets linked to metabolism and immune response regulation, and increases macrophage secretion of pro-inflammatory markers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Q9NZC2-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 146.57 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
EOS-215
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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