IA9 TFA
Based on 2 publication(s) in Google Scholar
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.90%
- Formel: C51H88N10O10.xC2HF3O2
- Molecular Weight:1001.31 (free acid)
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) IA9 TFA
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
TREM-2 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male DBA/1J mice (7-9 weeks old) subcutaneously injected with type II collagen[1]
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Dosage:2.5 and 25 mg/kg
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Administration:i.p., daily for 14 days from day 28
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Result:Resulted in an increase in body weight.
Significantly reduced all six-joint mean histopathological parameters compared to vehicle-treated mice at the dose of 25 mg/kg.
Significantly reduced joint damage and bone erosion in CIA in a specific- and dose-dependent manner.
Reduced plasma and joint proinflammatory cytokine (IL-6, IL-1β, TNF-α, CSF-1) levels in a specific and dose-dependent manner.
Significantly reduced the number of inflammatory cells in the synovial membrane of the joints.
Chemical Information
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Appearance Solid
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Molecular Weight 1001.31 (free acid)
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Formel C51H88N10O10.xC2HF3O2
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Color White to off-white
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Synonyms
human TREM-2 182-190 TFA
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Sequence
Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala
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Sequence Shortening
IFLIKILAA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. [Abstract]2026 Apr;28(4):707-724. PMID: 41760931 -
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 6.25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IA9 TFA Related Classifications
HY-P10136A Related Classifications
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