IA9 TFA
Based on 2 publication(s) in Google Scholar
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.90%
- 分子式: C51H88N10O10.xC2HF3O2
- 分子量:1001.31 (free acid)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 IA9 TFA
More
生物活性
製品説明
IC50 & Target
[1]|
TREM-2 |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male DBA/1J mice (7-9 weeks old) subcutaneously injected with type II collagen[1]
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Dosage:2.5 and 25 mg/kg
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Administration:i.p., daily for 14 days from day 28
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Result:Resulted in an increase in body weight.
Significantly reduced all six-joint mean histopathological parameters compared to vehicle-treated mice at the dose of 25 mg/kg.
Significantly reduced joint damage and bone erosion in CIA in a specific- and dose-dependent manner.
Reduced plasma and joint proinflammatory cytokine (IL-6, IL-1β, TNF-α, CSF-1) levels in a specific and dose-dependent manner.
Significantly reduced the number of inflammatory cells in the synovial membrane of the joints.
化学情報
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性状 Solid
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分子量 1001.31 (free acid)
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分子式 C51H88N10O10.xC2HF3O2
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Color White to off-white
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別名
human TREM-2 182-190 TFA
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配列
Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala
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シーケンスの短縮
IFLIKILAA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. [Abstract]2026 Apr;28(4):707-724. PMID: 41760931 -
溶剤 & 溶解度
体外:
DMSO : 6.25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
IA9 TFA 関連分類
HY-P10136A 関連分類
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