2. Immunology/Inflammation
  3. TREM receptor
  4. IA9 TFA

IA9 TFA  (Synonyms: human TREM-2 182-190 TFA)

Cat. No.: HY-P10136A Purity: 98.90%
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IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

IA9 TFA

IA9 TFA Chemical Structure

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Based on 2 publication(s) in Google Scholar

Other Forms of IA9 TFA:

IA9 TFA Related Antibodies

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TREM-1 TREM-2

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Description

IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research[1][2].

IC50 & Target[1]

TREM-2

 

In Vivo

IA9 (2.5 and 25 mg/kg, i.p., daily for 14 days from day 28) TFA exerts anti-inflammatory and anti-arthritic effects in a CIA mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/1J mice (7-9 weeks old) subcutaneously injected with type II collagen[1]
Dosage: 2.5 and 25 mg/kg
Administration: i.p., daily for 14 days from day 28
Result: Resulted in an increase in body weight.
Significantly reduced all six-joint mean histopathological parameters compared to vehicle-treated mice at the dose of 25 mg/kg.
Significantly reduced joint damage and bone erosion in CIA in a specific- and dose-dependent manner.
Reduced plasma and joint proinflammatory cytokine (IL-6, IL-1β, TNF-α, CSF-1) levels in a specific and dose-dependent manner.
Significantly reduced the number of inflammatory cells in the synovial membrane of the joints.
Molecular Weight

1001.31 (free acid)

Formula

C51H88N10O10.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala
Sequence Shortening

IFLIKILAA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 6.25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation

Purity: 98.90%

SDS (252 KB)

COA (247 KB) RP-HPLC (99 KB) MS (141 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)
References
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IA9 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IA9human TREM-2 182-190IA 9IA-9TREM receptorTriggering receptors expressed on myeloid cellstriggering receptors expressed on myeloid cellsTREM-1TREM-2inflammationinnate immunitymacrophagesrheumatoid arthritisInhibitorinhibitorinhibit

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