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Cat. No.: HY-12095

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CB1 inverse agonist 2

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CB1 inverse agonist 2 is an orally active inverse agonist of Cannabinoid Receptor CB1. CB1 inverse agonist 2 effectively inhibits CP55940-induced hypothermia and anorexia in mice model.

For research use only. We do not sell to patients.

Purity: 99.15%
CAS No.: 1019839-52-1
Formula: C₂₄H₂₀ClFN₂OS
Molecular Weight:438.94

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

CB1 inverse agonist 2 Chemical Structure

CAS No.: 1019839-52-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

CB1 inverse agonist 2 is an orally active inverse agonist of Cannabinoid Receptor CB1. CB1 inverse agonist 2 effectively inhibits CP55940-induced hypothermia and anorexia in mice model^[1].

IC₅₀ & Target^[1]

CB1

9.7 (pKi)

CB2

6.0 (pKi)

All Cannabinoid Receptor Isoforms :

In Vitro

CB1 inverse agonist 2 (compound 12 h) shows selectivity on CB1 over CB2 with pK_i values of 9.7 and 6.0, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CB1 inverse agonist 2 (compound 12 h) (1 mg/kg; i.p.; single dose) results 70% inhibition against hypothermia, as well as (10 mg/kg; p.o.; single dose) resulting 59% inhibition against food intake^[1].
CB1 inverse agonist 2 (10 mg/kg; p.o.; once daily for 14 d) produces robust weight loss of approximately 13% of initial body weight in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1019839-52-1
Appearance Solid
Molecular Weight 438.94
Formula C₂₄H₂₀ClFN₂OS
Color Off-white to light yellow
SMILES

O=C(C1=CC=C2SC3=CC=CC=C3C(C4=CC=C(F)C(Cl)=C4)=NC2=C1)NCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Synthesis and Evaluation of Dibenzothiazepines: A Novel Class of Selective Cannabinoid-1 Receptor Inverse Agonists J. Med. Chem., 2009, 52 (7), pp 1975-1982

[2]. Pettersson H, et al. Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. J Med Chem. 2009 Apr 9;52(7):1975-82. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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CB1 inverse agonist 2

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

Orally Active Compound Library

Anti-Prostate Cancer Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

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MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CB1 inverse agonist 2

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

Orally Active Compound Library

Anti-Prostate Cancer Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CB1 inverse agonist 2 Related Classifications

Cat. No.: HY-12095