EP2 receptor agonist 2
EP2 receptor agonist 2 (compound 18a) is a potent and selective G protein-biased EP2 receptor agonist (hEP2G protein EC50 = 13 nM, hEP2β arrestin EC50 > 10000 nM). EP2 receptor agonist 2 exhibits excellent selectivity over hEP1/3/4, hIP and hFP (EC50s > 10000 nM).
For research use only. We do not sell to patients.
- CAS No.: 1807780-00-2
- Formula: C19H21NO5S
- Molecular Weight:375.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EP2 13 nM (EC50) |
hEP1 >10000 nM (EC50) |
hEP3 >10000 nM (EC50) |
hEP4 >10000 nM (EC50) |
hFP >10000 nM (EC50) |
hIP >10000 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
>10 μM
Compound: 18a
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Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis
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[PMID: 26985320] |
| CHO | EC50 |
13 nM
Compound: 1
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Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay
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[PMID: 27055938] |
| CHO | EC50 |
13 nM
Compound: 18a
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Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
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[PMID: 26985320] |
| HEK293 | EC50 |
>10 μM
Compound: 1
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Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay
Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay
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[PMID: 27055938] |
| HEK293 | EC50 |
>10 μM
Compound: 18a
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Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay
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[PMID: 26985320] |
Chemical Information
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CAS No. 1807780-00-2
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Molecular Weight 375.44
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Formula C19H21NO5S
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SMILES
OC(C1=CSC([C@@H](CC2)O[C@](C[C@H]3O)([H])[C@@]2([H])[C@H]3COC4=CC=CC=C4)=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EP2 receptor agonist 2 Related Classifications
HY-128496 Related Classifications
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