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Iluzanebart

(Synonyms: VGL101)
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Based on 1 Customer Validation

Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP).

For research use only. We do not sell to patients.

  • Purity: 98.63%
  • CAS No.: 2733621-19-5
  • Molecular Weight:144.92 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Iluzanebart
  • Experimental Validation Results for Iluzanebart
  • Experimental Validation Results for Iluzanebart
  • Iluzanebart Chemical Structure
    Iluzanebart Chemical Structure
CAS No.: 2733621-19-5
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Iluzanebart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All TREM receptor Isoforms

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized TREM-2 Protein, Human can bind Iluzanebart. The EC50 for this effect is 178.6 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells with Iluzanebart (HY-P990043, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Iluzanebart Chemical Structure
    1/16
  • Iluzanebart
  • Immobilized TREM-2 Protein, Human can bind Iluzanebart. The EC50 for this effect is 178.6 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells with Iluzanebart (HY-P990043, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).