RXFP2 agonist 2
RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC50 value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.
For research use only. We do not sell to patients.
- CAS No.: 2971704-85-3
- Formula: C29H19F9IN3O5
- Molecular Weight:787.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 0.38 µM (RXFP2)[1]
RXFP2 agonist 2 (Compound 6641) (1, 3, 5 µM; 14 days) induces osteoblast mineralization at 3 and 5 µM with no cytotoxicity in HCO cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCO cells
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Concentration:0-100 µM
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Incubation Time:14 days
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Result:Induced mineralization of primary human osteoblasts and is non-cytotoxic.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old WT C57BL/6 J female mice[1]
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Dosage:3 mg/kg for i.v.; 10 mg/kg for p.o.
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Administration:I.v. or p.o.
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Result:Exhibited a half-life of between 4-6.5 h depending on the route of administration, with no accumulation at 10 mg/kg, and oral bioavailability around 25-31%.
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Animal Model:8-week-old WT C57BL/6 J female mice[1]
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Dosage:10 mg/kg
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Administration:P.o.; 3 times per week for 8 weeks
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Result:Increased bone formation in mouse with significantly increased in Tb.N and Tb.Th, and increased BV/TV and decreased Tb.Sp.
Chemical Information
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CAS No. 2971704-85-3
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Molecular Weight 787.37
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Formula C29H19F9IN3O5
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SMILES
O=C(N1[C@H]2CN(CC1)C(COC3=CC=C(C=C3I)OC(F)(F)F)=O)C4=CC(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=CC=C4NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RXFP2 agonist 2 Related Classifications
HY-150186 Related Classifications
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