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Cat. No.: HY-150186A

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(R)-RXFP2 agonist 2

Name: (R)-RXFP2 agonist 2
Brand: MedChemExpress
SKU: HY-150186A
Price: 570.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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(R)-RXFP2 agonist 2 is the R-type isomer of RXFP2 agonist 2 (HY-150186). RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC₅₀ value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.

For research use only. We do not sell to patients.

CAS No.: 3123585-08-7
Formula: C₂₉H₁₉F₉IN₃O₅
Molecular Weight:787.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

(R)-RXFP2 agonist 2 Chemical Structure

CAS No.: 3123585-08-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
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Biological Activity

Description

IC₅₀ & Target

^[1]

RXFP2

Chemical Information

CAS No. 3123585-08-7
Molecular Weight 787.37
Formula C₂₉H₁₉F₉IN₃O₅
SMILES

O=C(N1[C@@H]2CN(CC1)C(COC3=CC=C(C=C3I)OC(F)(F)F)=O)C4=CC(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=CC=C4NC2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Mesenchymal stromal/stem cell osteogenic differentiation
Mesenchymal stromal/stem cells can be induced toward an osteoblast-like lineage in vitro by culture in osteogenic medium containing dexamethasone, ascorbic acid or ascorbate-2-phosphate, and β-glycerophosphate; the differentiation process is commonly evaluated by alkaline phosphatase activity, osteogenic marker expression, collagenous matrix formation, and calcium-rich matrix mineralization. The main readouts are alkaline phosphatase activity as an early osteogenic marker and Alizarin Red S staining as a calcium-deposit readout for mineralized extracellular matrix; Alizarin Red S can be inspected microscopically or extracted and measured colorimetrically at 405 nm.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Esteban-Lopez M, et al. Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun Biol. 2022 Nov 4;5(1):1183. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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