CB2 receptor agonist 2
CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1314230-75-5
- Formula: C30H36N2O4
- Molecular Weight:488.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CB2 8.5 nM (Ki) |
CB2 receptor agonist 2 (compound 4g) (1 μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hep-G2 (Human hepatoblastoma) cells
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Concentration:1 μM
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Incubation Time:72 hours
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Result:Exhibited very low or no cytotoxicity to Hep-G2 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Formalin injection induces a biphasic stereotypical nocifensive behavior in mice[1]
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Dosage:Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour
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Administration:Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)
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Result:Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.
Chemical Information
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CAS No. 1314230-75-5
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Appearance Solid
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Molecular Weight 488.62
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Formula C30H36N2O4
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Color White to light yellow
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SMILES
O=C(C1=CN(CCCCC)C2=C(C1=O)C=C(C3=CC=CO3)C=C2OC)NC45CC6CC(C5)CC(C4)C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : 30 mg/mL (61.40 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.0466 mL | 10.2329 mL | 20.4658 mL | 51.1645 mL |
| 5 mM | 0.4093 mL | 2.0466 mL | 4.0932 mL | 10.2329 mL | |
| 10 mM | 0.2047 mL | 1.0233 mL | 2.0466 mL | 5.1165 mL | |
| 15 mM | 0.1364 mL | 0.6822 mL | 1.3644 mL | 3.4110 mL | |
| 20 mM | 0.1023 mL | 0.5116 mL | 1.0233 mL | 2.5582 mL | |
| 25 mM | 0.0819 mL | 0.4093 mL | 0.8186 mL | 2.0466 mL | |
| 30 mM | 0.0682 mL | 0.3411 mL | 0.6822 mL | 1.7055 mL | |
| 40 mM | 0.0512 mL | 0.2558 mL | 0.5116 mL | 1.2791 mL | |
| 50 mM | 0.0409 mL | 0.2047 mL | 0.4093 mL | 1.0233 mL | |
| 60 mM | 0.0341 mL | 0.1705 mL | 0.3411 mL | 0.8527 mL |
CB2 receptor agonist 2 Related Classifications
HY-132217 Related Classifications
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