1. GPCR/G Protein Neuronal Signaling
  2. Cannabinoid Receptor
  3. CB2 receptor agonist 2

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.

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CB2 receptor agonist 2 Chemical Structure

CB2 receptor agonist 2 Chemical Structure

CAS No. : 1314230-75-5

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Description

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2[1].

IC50 & Target[1]

CB2

8.5 nM (Ki)

In Vitro

CB2 receptor agonist 2 (compound 4g) (1  μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Hep-G2 (Human hepatoblastoma) cells
Concentration: 1  μM
Incubation Time: 72 hours
Result: Exhibited very low or no cytotoxicity to Hep-G2 cells.
In Vivo

CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Formalin injection induces a biphasic stereotypical nocifensive behavior in mice[1]
Dosage: Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour
Administration: Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)
Result: Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.
Molecular Weight

488.62

Formula

C30H36N2O4

CAS No.
SMILES

O=C(C1=CN(CCCCC)C2=C(C1=O)C=C(C3=CC=CO3)C=C2OC)NC45CC6CC(C5)CC(C4)C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CB2 receptor agonist 2 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CB2 receptor agonist 2
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HY-132217
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