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Cat. No.: HY-W746031

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WAY-181187 hydrochloride

(Synonyms: SAX-187 hydrochloride)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.

For research use only. We do not sell to patients.

CAS No.: 554403-08-6
Formula: C₁₅H₁₄Cl₂N₄O₂S₂
Molecular Weight:417.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

WAY-181187 hydrochloride Chemical Structure

CAS No.: 554403-08-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM^[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist^[2].

IC₅₀ & Targetsup>[1]

5-HT₆ Receptor

2.2 nM (Ki)

5-HT₆ Receptor

6.6 nM (EC₅₀)

All 5-HT Receptor Isoforms :

In Vitro

WAY-181187 (1 and 10 μM) hydrochloride increases activation of ERK1/2. WAY-181187 hydrochloride also increases Fyn kinase activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acute administration of WAY-181187 (3-30 mg/kg, s.c.) hydrochloride significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 (30 mg/kg, s.c.) hydrochloride produces modest yet significant decreases in cortical dopamine and 5-HT levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Sprague-Dawley rats weighing 280-350 g^[1]
Dosage:

3, 10, or 30 mg/kg
Administration:

Acute dministered by s.c.
Result:

Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

Chemical Information

CAS No. 554403-08-6
Molecular Weight 417.33
Formula C₁₅H₁₄Cl₂N₄O₂S₂
SMILES

NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4.[H]Cl
Synonyms

SAX-187 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Thromb Res

Prognostic gene landscapes and therapeutic insights in sepsis-induced coagulopathy. [Abstract]

2024 May:237:1-13. PMID: 38513536
SSRN

2025 Aug 7.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]

[2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

WAY-181187 hydrochloride

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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WAY-181187 hydrochloride

Publications Citing Use of MedChemExpress (MCE) WAY-181187 hydrochloride

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

WAY-181187 hydrochloride Related Classifications

HY-W746031 Related Classifications