1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. TLR8 agonist 2 hydrochloride

TLR8 agonist 2 hydrochloride 

Cat. No.: HY-141454A
Handling Instructions

TLR8 agonist 2 hydrochloride is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC50 of 33.33 μM).

For research use only. We do not sell to patients.

TLR8 agonist 2 hydrochloride Chemical Structure

TLR8 agonist 2 hydrochloride Chemical Structure

CAS No. : 2412937-65-4

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Description

TLR8 agonist 2 hydrochloride is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC50 of 33.33 μM)[1].

IC50 & Target[1]

TLR8

3 nM (EC50)

TLR7

33.33 μM (EC50)

In Vitro

TLR8 agonist 2 (Example 1) increases the levels of TNF-α, IL-12p40, IFN-γ, and IFN-α with EC50 values 105 nM, 26 nM, 29 nM, and 2800 nM, respectively, in human peripheral blood mononuclear cells (hPBMC)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T1/2 of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUClast are 450 ng/mL*hr (i.v.) and 624 ng/mL*hr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C₁₆H₂₂N₈.xHCl

CAS No.
SMILES

CCCC[[email protected]@](CC1=NN=CN1)(C)NC2=NC(N)=NC3=C2C=CN=C3.[x].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TLR8 agonist 2Toll-like Receptor (TLR)TLR8TNF-αIL-12p40IFN-γIFN-αInhibitorinhibitorinhibit

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Product Name:
TLR8 agonist 2 hydrochloride
Cat. No.:
HY-141454A
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