2. GPCR/G Protein
  3. Adenosine Receptor
  4. 2-Chloro-N-cyclopentyl-2′-C-methyladenosine

2-Chloro-N-cyclopentyl-2′-C-methyladenosine 

Cat. No.: HY-103180 Purity: 99.79%
COA Handling Instructions

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2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs).

For research use only. We do not sell to patients.

2-Chloro-N-cyclopentyl-2′-C-methyladenosine Chemical Structure

2-Chloro-N-cyclopentyl-2′-C-methyladenosine Chemical Structure

CAS No. : 205171-12-6

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5 mg USD 250 In-stock
10 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

2-Chloro-N-cyclopentyl-2′-C-methyladenosine Related Antibodies

Top Publications Citing Use of Products

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

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Description

2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs)[1][2].

IC50 & Target[1]

A1AR

 

In Vivo

2’-MeCCPA (1?nM-1 M) at reperfusion significantly reduces infarct size to risk ratio in male Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

383.83

Formula

C16H22ClN5O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=NC2=C(C(NC3CCCC3)=N1)N=CN2[C@H]4[C@@](O)(C)[C@H](O)[C@@H](CO)O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (651.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6053 mL 13.0266 mL 26.0532 mL
5 mM 0.5211 mL 2.6053 mL 5.2106 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (255 KB) HNMR (293 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6053 mL 13.0266 mL 26.0532 mL 65.1330 mL
5 mM 0.5211 mL 2.6053 mL 5.2106 mL 13.0266 mL
10 mM 0.2605 mL 1.3027 mL 2.6053 mL 6.5133 mL
15 mM 0.1737 mL 0.8684 mL 1.7369 mL 4.3422 mL
20 mM 0.1303 mL 0.6513 mL 1.3027 mL 3.2567 mL
25 mM 0.1042 mL 0.5211 mL 1.0421 mL 2.6053 mL
30 mM 0.0868 mL 0.4342 mL 0.8684 mL 2.1711 mL
40 mM 0.0651 mL 0.3257 mL 0.6513 mL 1.6283 mL
50 mM 0.0521 mL 0.2605 mL 0.5211 mL 1.3027 mL
60 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0856 mL
80 mM 0.0326 mL 0.1628 mL 0.3257 mL 0.8142 mL
100 mM 0.0261 mL 0.1303 mL 0.2605 mL 0.6513 mL
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2-Chloro-N-cyclopentyl-2′-C-methyladenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Chloro-N-cyclopentyl-2′-C-methyladenosine205171-12-6Adenosine ReceptorP1 receptordMSNsiMSNscAMPInhibitorinhibitorinhibit

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