205171-12-6
Chemical Structure
2'-MeCCPA
Synonym(s): 2-Chloro-N-cyclopentyl-2′-C-methyladenosine
- CAS No.: 205171-12-6
- Formula:C16H22ClN5O4
- Molecular Weight:383.83
IUPAC Name: (2R,3R,4R,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
InChIKey: MMPAUXMIDJWGFO-ROMFRFKVSA-N
SMILES: ClC1=NC2=C(C(NC3CCCC3)=N1)N=CN2[C@H]4[C@@](O)(C)[C@H](O)[C@@H](CO)O4
Biological Activity: 2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2'-MeCCPA | 99.80% | 2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs). | ||||||||||||||||||||
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- [1]. J Bhandal, et al. Adenosine a1 receptor activation can protect the myocardium from ischaemia reperfusion injury post reperfusion. BMJ Journals. Volume 104, Issue Suppl 3.
- [2]. Muntean BS, et al. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268. [Content Brief]
Keywords
