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Cat. No.: HY-162552

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KOR/DOR agonist 1

KOR/DOR agonist 2 is a KOR and DOR opioid receptors agonist with K_i values of 0.14 nM, and 0.93 nM, respectively. KOR/DOR agonist 2 shows significant antinociceptive effects. KOR/DOR agonist 2 penetrates the blood-brain barrier.

For research use only. We do not sell to patients.

Formula: C₂₈H₃₂N₂O₅
Molecular Weight:476.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

KOR/DOR agonist 1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

κ Opioid Receptor/KOR

0.14 nM (Ki)

δ Opioid Receptor/DOR

0.2 nM (Ki)

μ Opioid Receptor/MOR

0.93 nM (Ki)

All Opioid Receptor Isoforms :

In Vitro

KOR/DOR agonist 2 (compound 21) has subnanomolar binding for the MOR, with a K_i of 0.20 nM^[1].
In [35S]-GTPγS-binding assay, KOR/DOR agonist 2 shows functional activity at the KOR, MOR, and DOR with an EC₅₀ values of 0.04 nM, 0.58 nM, 1.28 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KOR/DOR agonist 2 (0.1 mg/kg; subcutaneous injection; once) results in significant antinociceptive effects in a warm-water tail immersion assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Swiss Webster mice (6-8 week-old)^[1]
Dosage:

0.1 mg/kg
Administration:

Subcutaneous injection; once
Result:

Showed significant antinociceptive effects.

Chemical Information

Molecular Weight 476.56
Formula C₂₈H₃₂N₂O₅
SMILES

O[C@]12[C@@]3(C4=C(C(O)=CC=C4C[C@H]2N(CC3)CC5CC5)O6)[C@@H]6[C@H](CC1)N(C(/C=C/C7=CC=CO7)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Celsey M St Onge, et al. Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. J Med Chem. 2024 May 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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KOR/DOR agonist 1

All Opioid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KOR/DOR agonist 1 Related Classifications

HY-162552 Related Classifications