1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. (2R,4R)-APDC

(2R,4R)-APDC 

Cat. No.: HY-102091
Handling Instructions

(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects.

For research use only. We do not sell to patients.

(2R,4R)-APDC Chemical Structure

(2R,4R)-APDC Chemical Structure

CAS No. : 169209-63-6

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Description

(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects[1][2].

In Vivo

2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus[2].

Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g[2]
Dosage: 1 nmol/10 μl; 10 nmol/10μl
Administration: ICV; daily for 14 days
Result: Resulted in decreased BrdU-immunoreactive cells in the DG.
Molecular Weight

174.15

Formula

C₆H₁₀N₂O₄

CAS No.

169209-63-6

SMILES

O=C([[email protected]@H]1NC[[email protected]](C(O)=O)(N)C1)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(2R,4R)-APDCmGluRMetabotropic glutamate receptorsanticonvulsantneuroprotectivecellproliferationdentategyrusInhibitorinhibitorinhibit

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(2R,4R)-APDC
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