2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation

  • Neuroreport. 2007 Sep 17;18(14):1459-62. doi: 10.1097/WNR.0b013e3282ef773e.
Hong Yao  1 ,  Jing Gao ,  Ya-Bo Feng ,  Zai-Ying Pang ,  Zhao-Fu Chi
Affiliations
  • 1. Department of Neurology, Qilu Hospital, Medical School of Shandong University, Jinan 250021, China.
PMID: 17712274 DOI: 10.1097/WNR.0b013e3282ef773e
Abstract

This study investigated the effects of group II metabotropic glutamate receptor agonist, 2R, 4R-4-aminopyrrolidine-2,4-dicarboxylate (2R, 4R-APDC), on cell proliferation in the dentate gyrus of adult rats. 2R, 4R-APDC at a dose of 1 and 10 nmol/day resulted in decreased bromodeoxyuridine immunoreactive cells in the dentate gyrus. In addition, we found that APDC treatment had no effect on the number of BrdU+ and GFAP(+)-labeled cells or BrdU+ and NeuN(+)-labeled cells compared with controls. These data suggest that group II metabotropic glutamate receptor is an important site for glutamate's regulation on cell proliferation in the dentate gyrus, but 2R, 4R-APDC had no effects on newborn cell's ability to differentiate into neurons or astrocytes.

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