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Cat. No.: HY-178492

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TRPA1 agonist-2

TRPA1 agonist-2 (Compound 4B) is an orally active and highly selective TRPA1 channel agonist. TRPA1 agonist-2 triggers calcium influx and stimulates GLP-1 secretion. TRPA1 agonist-2 is promising for research of diabetes, obesity, and related neurodegenerative diseases.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₉F₃N₂O₂
Molecular Weight:388.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TRPA1 agonist-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All TRP Channel Isoforms :

Chemical Information

Molecular Weight 388.38
Formula C₂₁H₁₉F₃N₂O₂
SMILES

O=C(CC1=CC=CC=C1)N2C[N@@](CC=C[C@H]3O2)[C@@]3([H])C4=CC(C(F)(F)F)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Comparini LM, et al. Synthesis and biological evaluation of N-O heterobicyclic ring systems derived from 1,2-dihydropyridines as novel TRPA1 activators: implication in GLP-1 release and neuroprotection. Eur J Med Chem. 2025 Dec 15;300:118115. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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TRPA1 agonist-2

All TRP Channel Isoforms