2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. EphA2 agonist 2

EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB.

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EphA2 agonist 2

EphA2 agonist 2 Chemical Structure

CAS No. : 2169273-66-7

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Based on 1 publication(s) in Google Scholar

EphA2 agonist 2 Related Antibodies

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Description

EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB[1].

Cellular Effect
Cell Line Type Value Description References
U-251 IC50
2.1 μM
Compound: Table 4, Lead cpd
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32828423]
U-251 IC50
5.2 μM
Compound: Table 4, Lead cpd
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32828423]
In Vitro

EphA2 agonist 2 (Lead compound) shows antiproliferation activity with IC50 values of 2.1 ± 1.05 μM and 5.2 ± 2.56 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EphA2 agonist 2 Related Antibodies
Molecular Weight

772.94

Formula

C40H56N10O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)CCCCCCCCCCC(N4CCN(C5=NC(N)=C6C=C(OC)C(OC)=CC6=N5)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (6.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2938 mL 6.4688 mL 12.9376 mL
5 mM 0.2588 mL 1.2938 mL 2.5875 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2938 mL 6.4688 mL 12.9376 mL 32.3440 mL
5 mM 0.2588 mL 1.2938 mL 2.5875 mL 6.4688 mL
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EphA2 agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EphA2 agonist 22169273-66-7Ephrin ReceptorU251antitumorBBBInhibitorinhibitorinhibit

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