126 Results for "

anti-apoptotic activities

" in MedChemExpress (MCE) Product Catalog:
Products (126)

126 Results for "anti-apoptotic activities" in MCE Product Catalog:

28
Naringin
Naringin
0 Images
28 Publications Verification
Cat. No.: HY-N0153
CAS No.: 10236-47-2
Synonyms: Naringoside
Category:  

Citrus × aurantium Linnaeus Flavonoids Leguminosae Flavonones Rutaceae Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Cytochrome P450 Autophagy Mitophagy Endogenous Metabolite

Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
loading...
    loading...
View All Sizes
23
Degrasyn
Degrasyn
0 Images
23 Cited Publications
Cat. No.: HY-13264
CAS No.: 856243-80-6
Purity:  99.70%
Synonyms: WP1130
Target:  

Deubiquitinase Bcr-Abl Autophagy Apoptosis

Research Areas:  

Cancer

Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.
loading...
    loading...
View All Sizes
14
Clemastine fumarate
Clemastine fumarate
0 Images
14 Cited Publications
Cat. No.: HY-B0298A
CAS No.: 14976-57-9
Synonyms: HS-592 fumarate; Meclastine fumarate
Target:  

Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK

Research Areas:  

Neurological Disease Metabolic Disease

Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
loading...
    loading...
View All Sizes
14
Clemastine
Clemastine
0 Images
14 Cited Publications
Cat. No.: HY-B0298
CAS No.: 15686-51-8
Synonyms: HS-592; Meclastine
Target:  

Histamine Receptor mAChR Autophagy Apoptosis Keap1-Nrf2 p62 mTOR Pyroptosis IKK

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
loading...
    loading...
View All Sizes
13
Ginkgolide B
Ginkgolide B
0 Images
13 Cited Publications
Cat. No.: HY-N0784
CAS No.: 15291-77-7
Synonyms: BN-52021
Category:  

Ginkgoaceae Terpenoids Ginkgo biloba L. Diterpenoids Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

Platelet-activating Factor Receptor (PAFR) Apoptosis

Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .
loading...
    loading...
View All Sizes
12
4,5-Dicaffeoylquinic acid
4,5-Dicaffeoylquinic acid
0 Images
12 Cited Publications
Cat. No.: HY-N0058
CAS No.: 57378-72-0
Synonyms: Isochlorogenic acid C; 4,5-diCQA
Category:  

Infection Ketones, Aldehydes, Acids Phenols Polyphenols Plants Bowdichia virgilioides Compositae Endogenous metabolite Disease Research Fields

Target:  

HBV Endogenous Metabolite Apoptosis Glycosidase

4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .
loading...
    loading...
View All Sizes
11
Angelicin
Angelicin
0 Images
11 Cited Publications
Cat. No.: HY-N0763
CAS No.: 523-50-2
Synonyms: Isopsoralen
Category:  

Leguminosae Coumarins Psoralea corylifolia L. Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.
loading...
    loading...
View All Sizes
8
Eupatilin
Eupatilin
0 Images
8 Cited Publications
Cat. No.: HY-N0783
CAS No.: 22368-21-4
Category:  

Flavonoids Neurological Disease Flavones Plants Compositae Disease Research Fields Sindora sumatrana Miq. Cancer

Target:  

PPAR Autophagy

Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
loading...
    loading...
View All Sizes
5
Epimedin B
Epimedin B
0 Images
5 Cited Publications
Cat. No.: HY-N0259
CAS No.: 110623-73-9
Synonyms: Epmedin B
Category:  

Flavonols Flavonoids Monophenols Other Diseases Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields

Target:  

JNK Estrogen Receptor/ERR p38 MAPK PI3K Akt AMPK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Bcl-2 Family

Epimedin B (Epmedin B) is a flavonoid active component found in Epimedium, with oral activity, and exhibits anti-osteoporotic and neuroprotective effects. Epimedin B inhibits RANKL-induced osteoclast differentiation, F-actin ring formation, and mature osteoclast bone resorption, inhibits the phosphorylation of JNK, p38 MAPK, PI3K, and AKT, activates the AMPK-Nrf2 antioxidant pathway, and reduces cellular and mitochondrial ROS. Epimedin B acts on ESR1 and exerts its effects via GPER. Epimedin B alleviates bone loss and improves bone microstructure in vivo, and in Parkinson's models protects dopaminergic neurons and maintains striatal dopamine levels through anti-apoptotic and anti-endoplasmic reticulum stress effects. Epimedin B can be used for research related to osteoporosis, diabetic osteoporosis, and Parkinson's disease .
loading...
    loading...
View All Sizes
5
Naringin Dihydrochalcone
Naringin Dihydrochalcone
0 Images
5 Cited Publications
Cat. No.: HY-N0119
CAS No.: 18916-17-1
Synonyms: Naringin DC
Category:  

Plants Dihydrochalcones Sweeteners Food Research other families Flavonoids Phenols Polyphenols Disease Research Fields Cancer

Target:  

NF-κB

Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
loading...
    loading...
View All Sizes
5
Mulberroside A
Mulberroside A
0 Images
5 Cited Publications
Cat. No.: HY-N0619
CAS No.: 102841-42-9
Category:  

Stilbenes Morus alba L. Phenols Polyphenols Plants Moraceae Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor Interleukin Related Tyrosinase

Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
loading...
    loading...
View All Sizes
4
Sweroside
Sweroside
0 Images
4 Cited Publications
Cat. No.: HY-N0806
CAS No.: 14215-86-2
Category:  

Monophenols Labiatae Lespedeza tomentosa (Thunb.) Siebold ex Maxim. Metabolic Disease Phenols Plants Disease Research Fields

Target:  

Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
loading...
    loading...
View All Sizes
4
Flavokawain C
Flavokawain C
0 Images
4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
Category:  

Piperaceae Plants other families Flavonoids Chalcones Piper methysticum G.Forst. Phenols Polyphenols Disease Research Fields Cancer

Target:  

Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK

Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .
loading...
    loading...
View All Sizes
2
Acetyl-L-carnitine hydrochloride
Acetyl-L-carnitine hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-B0762
CAS No.: 5080-50-2
Synonyms: O-Acetyl-L-carnitine hydrochloride; ALCAR hydrochloride
Category:  

Alkaloids Other Alkaloids Endogenous metabolite

Target:  

Caspase Apoptosis

Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression .
loading...
    loading...
View All Sizes
2
UNC0321
UNC0321
0 Images
2 Cited Publications
Cat. No.: HY-10930
CAS No.: 1238673-32-9
Purity:  99.91%
Target:  

Histone Methyltransferase GCGR Apoptosis

Research Areas:  

Cancer

UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications .
loading...
    loading...
View All Sizes
1
Caftaric acid
Caftaric acid
0 Images
1 Cited Publications
Cat. No.: HY-N0321
CAS No.: 67879-58-7
Synonyms: trans-Caftaric acid
Category:  

other families Microorganisms Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Others

Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities .
loading...
    loading...
View All Sizes
1
8-​O-​Acetylharpagide
8-​O-​Acetylharpagide
0 Images
1 Cited Publications
Cat. No.: HY-N0757
CAS No.: 6926-14-3
Category:  

Infection other families Iridoids Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Akt Bcl-2 Family Apoptosis Adrenergic Receptor

8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor .
loading...
    loading...
View All Sizes
1
Vitexin 4'-glucoside
Vitexin 4'-glucoside
0 Images
1 Cited Publications
Cat. No.: HY-N4085
CAS No.: 38950-94-6
Synonyms: 4'-O-Glucosylvitexin
Category:  

other families Flavonoids Flavones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

Reactive Oxygen Species (ROS) Apoptosis

Vitexin 4'-glucoside is a flavonoid C-glycoside with antioxidant and anti-apoptotic activities. Vitexin 4'-glucoside reduces the hydrogen peroxide-induced increase in caspase-3 activity. Vitexin 4'-glucoside ameliorates hydrogen peroxide-induced toxicity, apoptosis, morphological distortion, nuclear pyknosis, and the ratio of apoptotic/necrotic cells .
loading...
    loading...
View All Sizes
1
Olprinone
Olprinone
0 Images
1 Cited Publications
Cat. No.: HY-14254A
CAS No.: 106730-54-5
Purity:  99.29%
Synonyms: Loprinone
Target:  

Phosphodiesterase (PDE) Apoptosis NF-κB p38 MAPK

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Olprinone (Loprinone) is a potent and selective phosphodiesterase 3 (PDE3) inhibitor, with IC50 values of 150, 100, 0.35, and 14 μM against PDE1, PDE2, PDE3, and PDE4, respectively. Olprinone exerts comprehensive protective effects including anti-inflammatory, antioxidant, and anti-apoptotic activities by elevating intracellular cAMP levels and inhibiting the NF-κB and MAPK signaling pathways. Olprinone can be used in studies related to lung injury, spinal cord injury, heart failure, myocardial ischemia-reperfusion injury, and cerebral ischemic injury .
loading...
    loading...
View All Sizes
1
Caudatin
Caudatin
0 Images
1 Cited Publications
Cat. No.: HY-N1983
CAS No.: 38395-02-7
Category:  

Asclepiadaceae Cynanchum otophyllum Schneid． Plants Cynanchum auriculatum Royle ex Wight Disease Research Fields Cancer Steroids

Target:  

Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR

Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL. Caudatin suppresses VEGF, FAK phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .
loading...
    loading...
View All Sizes
Assay Types