2-Tetralone
Based on 1 Customer Validation
2-Tetralone (Beta-Tetralone) is a cyclic bis-sterically hindered ketone and a ketone derivative of tetrafluoramine. 2-Tetralone exhibits anticancer activity, inhibits cell migration and proliferation, and induces apoptosis. 2-Tetralone is often used as a pharmaceutical intermediate in studies related to organic synthesis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.76%
- CAS No.: 530-93-8
- Formule: C10H10O
- Masse moléculaire:146.19
-
Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
|
Bcl-W |
In Vitro
2-Tetralone (Beta-Tetralone) (100-300 μM; 48 h) induces cell death, inhibits cell migration and proliferation, and triggers apoptosis in MCF-7 breast cancer cells [1].
2-Tetralone serves as a precursor for chlorine-substituted fused ring systems and optically enriched 2-tetralols, and acts as a substrate for asymmetric reduction by the secondary alcohol dehydrogenase (TeSADH) mutant from Thermoanaerobacter pseudoethanolicus to produce (S)-2-tetralol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7 breast cancer cells
-
Concentration:100, 300 μM
-
Incubation Time:48 h
-
Result:Exhibited 26.86% cell death in MCF‑7 cells at 300 μM in MTT cytotoxicity assay, with activity comparable to 100 μM Doxorubicin (HY-15142A).
-
Cell Line:MCF-7 breast cancer cells
-
Concentration:100, 300 μM
-
Incubation Time:48 h
-
Result:Restricted migration and proliferation of MCF‑7 cells at 100 μM and 300 μM in scratch wound‑healing assay, and caused cell death at the scratch border under 300 μM treatment.
-
Cell Line:MCF-7 breast cancer cells
-
Concentration:100, 300 μM
-
Incubation Time:48 h
-
Result:Induced apoptosis in MCF‑7 cells, with 44.77% PI‑positive apoptotic cells after 300 μM exposure.
Chemical Information
-
CAS No. 530-93-8
-
Appearance <18°C Solid,>18°C Liquid
-
Masse moléculaire 146.19
-
Formule C10H10O
-
Color Colorless to light yellow
-
SMILES
O=C1CC=2C=CC=CC2CC1
-
Synonyms
Beta-Tetralone
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
-
Fiche technique (284 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Tetralone Related Classifications
HY-30063 Related Classifications
Powered by Bioz
Keywords
- 2-Tetralone
- 530-93-8
- Beta-Tetralone
- Drug Intermediate
- Apoptosis
- W110G TeSADH
- 6-chloro-2-tetralone
- W110A TeSADH
- Thermoanaerobacter pseudoethanolicus secondary alcohol dehydrogenase
- 5-methoxy-2-tetralone
- TeSADH mutants
- 7-methoxy-2-tetralone
- 8-methoxy-2-tetralone
- (S)-2-tetralol
- wild-type TeSADH
- MCF?7
- apoptosis
- cancer
- Inhibitor
- inhibitor
- inhibit