2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 255

Anticancer agent 255 is a monocarbonylated curcumin-1,2,3-oxazole conjugate with significant anticancer activity. The IC50 values of Anticancer agent 255 in prostate cancer cells PC-3 and DU-145 are 8.8μM and 9.5μM respectively. The IC50 values of Anticancer agent 255 against breast cancer cells MCF-7, MDA-MB-231 and 4T1 are 6μM, 10μM and 6.4μM, showing good anti-cancer activity Effect. Anticancer agent 255 can induce mitochondria-mediated apoptosis in cancer cells and prevent cell cycle progression. Anticancer agent 255 down-regulated the cell proliferation marker PCNA and inhibited the activation of cell survival proteins. Anticancer agent 255 up-regulated the pro-apoptotic protein Bax and down-regulated the anti-apoptotic protein Bcl-2.

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Anticancer agent 255

Anticancer agent 255 Chemical Structure

CAS No. : 1983924-20-4

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Description

Anticancer agent 255 is a monocarbonylated curcumin-1,2,3-oxazole conjugate with significant anticancer activity. The IC50 values of Anticancer agent 255 in prostate cancer cells PC-3 and DU-145 are 8.8μM and 9.5μM respectively. The IC50 values of Anticancer agent 255 against breast cancer cells MCF-7, MDA-MB-231 and 4T1 are 6μM, 10μM and 6.4μM, showing good anti-cancer activity Effect. Anticancer agent 255 can induce mitochondria-mediated apoptosis in cancer cells and prevent cell cycle progression. Anticancer agent 255 down-regulated the cell proliferation marker PCNA and inhibited the activation of cell survival proteins. Anticancer agent 255 up-regulated the pro-apoptotic protein Bax and down-regulated the anti-apoptotic protein Bcl-2[1].

Cellular Effect
Cell Line Type Value Description References
4T1 IC50
18 μM
Compound: 17
Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
DU-145 IC50
9.5 μM
Compound: 17
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
HEK293 IC50
> 100 μM
Compound: 17
Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
MCF7 IC50
28.7 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
MDA-MB-231 IC50
10 μM
Compound: 17
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
PC-3 IC50
8.8 μM
Compound: 17
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
Molecular Weight

492.59

Formula

C31H29FN4O
CAS No.
SMILES

O=C1/C(CN(C/C1=C\C2=CC=C(C=C2)C)CC3=CN(N=N3)CC4=CC=CC=C4F)=C/C5=CC=C(C=C5)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 255 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2551983924-20-4Anticancer agent255Anticancer agent-255ApoptosisInhibitorinhibitorinhibit

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