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Cat. No.: HY-149009

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Bcl-2-IN-9

Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC₅₀ value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells.

For research use only. We do not sell to patients.

CAS No.: 2490542-33-9
Formula: C₂₇H₃₁N₇O₃S
Molecular Weight:533.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Bcl-2-IN-9 Chemical Structure

CAS No.: 2490542-33-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Bcl-2

2.9 μM (IC₅₀, ^[1])

All Bcl-2 Family Isoforms :

In Vitro

Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) inhibits HL-60 cells in vitro^[1].
Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) shows low cytotoxic effects against WI-38 cells with cell viability of 91%^[1].
Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) displays a high selectivity against leukemia cells^[1].
Bcl-2-IN-9 (compound 6e) (10 μM) mediates apoptotic by down-regulating expression of Bcl-2 and causing chromatin compaction and nuclear fragmentation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HL-60 cells
Concentration:

1, 10, 20, 40 μM
Incubation Time:

48 hours
Result:

Surpressed cell growth and viability to 28.9%.

Cell Cytotoxicity Assay^[1]

Cell Line:

WT-38 cells
Concentration:

10 μM
Incubation Time:

48 hours
Result:

Low cytotoxic effects.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

1, 10, 20, 40 μM
Incubation Time:

48 hours
Result:

Caused chromatin compaction and nuclear fragmentation.

Chemical Information

CAS No. 2490542-33-9
Molecular Weight 533.65
Formula C₂₇H₃₁N₇O₃S
SMILES

CN1CCN(C2=NC3=CC=CC=C3N=C2SC4=NN=C(C5=CC=C(OCCN6CCOCC6)C=C5)O4)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yukari Ono, et al. Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein. Bioorg Chem. 2020 Aug; 104: 104245.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Bcl-2-IN-9

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bcl-2-IN-9 Related Classifications

HY-149009 Related Classifications