Apoptosis inducer 39
Apoptosis inducer 39 is an apoptosis inducer with IC50s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C16H10BrF3N4O3
- Peso molecular:443.17
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Bcl-2 |
Apoptosis inducer 39 (Compound Y22) (5-40 μM, 0-24 h) decreases the number of MDA-MB-231 cells and causes the cells to shrink and form apoptotic vesicles[1].
Apoptosis inducer 39 (5-20 μM, 24 h) significantly inhibits cell migration and exerts the anti-tumor activity by inducing apoptosis in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 cells
-
Concentration:5, 10 and 20 μM
-
Incubation Time:24 h
-
Result:Inhibited cell migration in a dose-dependent manner.
-
Cell Line:MDA-MB-231 cells
-
Concentration:5, 10 and 20 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis in a concentration-dependent manner.
Increased the percentage of apoptotic cells from 3.97 % to 58.6 %.
-
Cell Line:MDA-MB-231 cells
-
Concentration:5, 10 and 20 μM
-
Incubation Time:24 h
-
Result:The pro-apoptotic protein Bax was significantly up-regulated and the expression of the antiapoptotic protein Bcl-2 was down-regulated.
Chemical Information
-
Peso molecular 443.17
-
Fòrmula C16H10BrF3N4O3
-
SMILES
O=[N+](C1=CC2=NC(C(F)(F)F)=NC(NC3=CC=C(OC)C(Br)=C3)=C2C=C1)[O-]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 39 Related Classifications
HY-174992 Related Classifications
Powered by Bioz