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Cat. No.: HY-174992

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Apoptosis inducer 39

Apoptosis inducer 39 is an apoptosis inducer with IC₅₀s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₀BrF₃N₄O₃
Molecular Weight:443.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Apoptosis inducer 39 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Bcl-2

All Bcl-2 Family Isoforms :

In Vitro

Apoptosis inducer 39 (Compound Y22) (5-40 μM, 0-24 h) decreases the number of MDA-MB-231 cells and causes the cells to shrink and form apoptotic vesicles^[1].
Apoptosis inducer 39 (5-20 μM, 24 h) significantly inhibits cell migration and exerts the anti-tumor activity by inducing apoptosis in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

5, 10 and 20 μM
Incubation Time:

24 h
Result:

Inhibited cell migration in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

5, 10 and 20 μM
Incubation Time:

24 h
Result:

Induced apoptosis in a concentration-dependent manner.
Increased the percentage of apoptotic cells from 3.97 % to 58.6 %.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

5, 10 and 20 μM
Incubation Time:

24 h
Result:

The pro-apoptotic protein Bax was significantly up-regulated and the expression of the antiapoptotic protein Bcl-2 was down-regulated.

Chemical Information

Molecular Weight 443.17
Formula C₁₆H₁₀BrF₃N₄O₃
SMILES

O=[N+](C1=CC2=NC(C(F)(F)F)=NC(NC3=CC=C(OC)C(Br)=C3)=C2C=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang M, et al. Synthesis of quinazoline derivatives and their in vitro inhibition activity against MDA-MB-231 cells and A549 cells. Bioorg Med Chem Lett. 2025 Nov 1;127:130308. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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