HBF-0079

Cat. No.: HY-18203: Data Sheet Handling Instructions
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HBF-0079 is a selective anti-hepatocellular carcinoma agent. HBF-0079 induces cell cycle arrest and Apoptosis. HBF-0079 modulates cell-growth and anti-apoptotic signaling through AKT and mTOR. HBF-0079 exhibits antitumor activity against hepatocellular carcinoma.

For research use only. We do not sell to patients.

HBF-0079 Chemical Structure

CAS No. : 315702-93-3

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mTOR mTORC1 mTORC2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	> 30 μM Compound: 10	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	[PMID: 18774291]
Huh-7	CC₅₀	1.1 μM Compound: HBF-0079	Cytotoxicity against human HuH7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HuH7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 27793566]

Molecular Weight

255.30

Formula

C₁₂H₉N₅S

CAS No.

315702-93-3

SMILES

C1(C2=CSC(NC3=NC=CC=N3)=N2)=NC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cuconati A, et al. Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells. PLoS One. 2013;8(1):e54595. [Content Brief]

HBF-0079 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBF-0079315702-93-3HBF0079HBF 0079ApoptosisAktmTORPKBProtein kinase BMammalian target of RapamycinHuh7Hep3BHepaRGHepG2Hepatocellular carcinomanude miceInhibitorinhibitorinhibit

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