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Results for "

protein+inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (2) Adrenergic Receptor (2) Akt (7) Amyloid-β (4) Androgen Receptor (1) Antibiotic (1) Apoptosis (26) Autophagy (6) Bacterial (7) Bcl-2 Family (16) BCRP (2) Biochemical Assay Reagents (1) c-Met/HGFR (3) c-Myc (2) Calcium Channel (5) Caspase (4) CDK (1) CETP (1) Cholinesterase (ChE) (1) Deubiquitinase (1) DNA-PK (1) DNA/RNA Synthesis (4) Dopamine β-hydroxylase (2) Drug Derivative (3) Drug Intermediate (1) Drug Metabolite (2) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (2) E3 Ligase Ligand-Linker Conjugates (1) EGFR (1) Enterovirus (2) Environmental Pollutants (1) Epigenetic Reader Domain (7) ERK (1) Estrogen Receptor/ERR (2) FAP (2) Fat Mass and Obesity-associated Protein (FTO) (2) Fluorescent Dye (1) Fungal (2) Glucocorticoid Receptor (1) Glycosidase (1) HBV (3) HCV (13) HCV Protease (1) Herbicide (1) Histone Methyltransferase (3) HIV (4) HSP (5) IAP (1) Insulin Receptor (1) Isotope-Labeled Compounds (4) Keap1-Nrf2 (1) LDLR (1) Ligands for Target Protein for PROTAC (2) MAGL (1) MALT1 (3) MDM-2/p53 (4) Microsomal Triglyceride Transfer Protein (MTP) (1) Microtubule/Tubulin (1) Mixed Lineage Kinase (4) MMP (4) mTOR (2) Na+/K+ ATPase (1) Necroptosis (2) NF-κB (7) NOD-like Receptor (NLR) (1) Orthopoxvirus (2) P2Y Receptor (2) p62 (1) Parasite (5) PD-1/PD-L1 (1) PDGFR (2) Penicillin-binding protein (PBP) (1) Photosystem II (1) PI3K (3) PKA (2) PKC (3) Porcupine (2) Potassium Channel (1) PROTACs (3) RAR/RXR (1) Ras (4) Reactive Oxygen Species (ROS) (5) Reference Standards (13) RGS Protein (1) RIP kinase (1) ROS Kinase (1) RSV (6) RUNX (1) SARS-CoV (3) SNIPERs (1) Survivin (1) Tau Protein (4) TGF-beta/Smad (2) Trk Receptor (2) VEGFR (2) Virus Protease (1) WDR5 (2) Wnt (2) YAP (1) α-synuclein (4)
By Research Areas:	Cancer (75) Cardiovascular Disease (12) Endocrinology (2) Infection (48) Inflammation/Immunology (10) Metabolic Disease (8) Neurological Disease (24)
Click Chemistry:	Tetrazine (1)

155

Inhibitors & Agonists

Fluorescent Dyes

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10087

Navitoclax Maximum Cited Publications 150 Publications Verification ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-B1192

Estradiol benzoate 15+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Estrogen Receptor/ERR HBV Bcl-2 Family	Neurological Disease
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-111557

YM-254890 15+ Cited Publications	P2Y Receptor	Cardiovascular Disease
YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y₁ signal transduction pathway, with an IC₅₀ value below 0.6 μM .

HY-101518

Alrizomadlin 4 Publications Verification APG-115; AA-115	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC₅₀ and K_i values of 3.8 nM and 1 nM, respectively . Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner .

HY-10969

Obatoclax Mesylate 10+ Cited Publications GX15-070 Mesylate	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .

HY-153714

Zefamenib BN-104; BNM-1192; Menin-MLL inhibitor 27	Epigenetic Reader Domain Potassium Channel	Cancer
Zefamenib (BN-104) is an effective selective brain membrane protein inhibitor with oral activity, and it's also a Menin inhibitor, it can block the Menin-MLL interaction and leads to the degradation of Menin protein. Zefamenib is a weak hERG inhibitor, with an IC₅₀ greater than 100 μM. Zefamenib has anti-tumor activity and can be used in cancer research, such as for acute myeloid leukemia .

HY-10466

Daclatasvir 45+ Cited Publications BMS-790052; EBP 883	HCV	Infection
Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

HY-100110

KNK437 5+ Cited Publications Heat Shock Protein Inhibitor I	HSP	Cancer
KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

HY-109142

Ziresovir 5 Publications Verification AK0529; RO-0529	RSV	Infection
Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC₅₀=3 nM) and highlights pharmacokinetics in animal species .

HY-122727

STL127705 5+ Cited Publications	DNA-PK Apoptosis	Cancer
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC₅₀ of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis .

HY-112292

GW806742X 20+ Cited Publications	Mixed Lineage Kinase VEGFR	Others
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X has activity against VEGFR2 (IC₅₀=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis .

HY-128902

MC-Val-Cit-PAB-vinblastine 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-vinblastine is a agent-linker conjugate for ADC with potent antitumor activity by using vinblastine (an microtubule protein inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

HY-16586

PFI-1 3 Publications Verification	Epigenetic Reader Domain Autophagy Apoptosis	Cancer
PFI-1, a chemical probe, is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC₅₀ of 0.22 μM in a cell-free assay.

HY-B0473

Tetracaine hydrochloride Amethocaine hydrochloride	Environmental Pollutants Calcium Channel	Neurological Disease
Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca ²⁺ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-120231

Z-VRPR-FMK	MALT1 NF-κB MMP	Cancer
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

HY-178842

Z52	Ras ADC Payload	Cancer
Z52 is a Ras protein inhibitor. Z52 can be used for the research of cancer, such as pancreatic cancer .

HY-112180

Rilematovir 5 Publications Verification JNJ-678; JNJ-53718678	RSV	Infection
Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research.

HY-111548

Spastazoline 4 Publications Verification	Microtubule/Tubulin	Others
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC₅₀ of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research .

HY-176471

IGF2BP3-IN-1	Insulin Receptor	Cancer
IGF2BP3-IN-1 (Compound I3IN-122) is an IGF2BP3 (a RNA binding protein) inhibitor (IC₅₀: > 50 μM), and can be used for cancer research .

HY-147110

APX2039	Fungal	Infection Inflammation/Immunology
APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei .

HY-109195

Vebicorvir 2 Publications Verification ABI-H0731	HBV	Infection Inflammation/Immunology
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC₅₀s from 1.84 μM to 7.3 μM .

HY-124718

*p32 Inhibitor* M36** M36	PKC	Cancer
p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1 .

HY-P99648

Gosuranemab BMS-986168; IPN007; BIIB092	Tau Protein	Neurological Disease
Gosuranemab (BMS-986168; IPN007; BIIB092) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease .

HY-P1407

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA	MALT1 NF-κB MMP	Cancer
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

HY-100408

GNF-6231	Wnt Porcupine	Cardiovascular Disease Cancer
GNF-6231 is a porcupine (IC₅₀= 0.8 nM), Pron, and endoplasmic reticulum protein inhibitor with oral activity. GNF-6231 has anticancer activity. GNF-6231 can prevent the activation of the Wnt pathway by blocking the secretion of all Wnt ligands. GNF-6231 can be used in the study of myocardial infarction .

HY-161409

SC912	Androgen Receptor Apoptosis	Cancer
SC912 is an AR-V7 inhibitor (IC₅₀ = 0.36 μM). SC912 possesses safety, potency and selectivity. SC912 binds directly to AR-FL and AR-V7 proteins, inhibites nuclear localization and chromatin binding capabilities. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis .

HY-173521

JNJ-9676	SARS-CoV DNA/RNA Synthesis Virus Protease	Infection
JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin .

HY-101460

Tz-Thalidomide	E3 Ligase Ligand-Linker Conjugates Drug Derivative	Cancer
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .

HY-177590

14-3-3-IN-2	MMP	Others
14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC₅₀ of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels .

HY-10969A

Obatoclax 10+ Cited Publications GX15-070	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity .

HY-10087R

Navitoclax (Standard) ABT-263 (Standard)	Reference Standards Bcl-2 Family	Cancer
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-153754

*Phosphatidylcholine transfer protein inhibitor-1*	Drug Derivative	Metabolic Disease
Phosphatidylcholine transfer protein inhibitor-1 (Answer 37 in Patent) is a *phosphatidylcholine transfer protein* (PC-TP)** inhibitor. Phosphatidylcholine transfer protein inhibitor-1 can be used for research of PC-TP related disease such as obesity .

HY-155472

*Mcl-1 inhibitor* 17**	Bcl-2 Family	Cancer
Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. Mcl-1 inhibitor 17 can be used for the research of cancer and other diseases .

HY-76667

3-(Boc-amino)propyl bromide	MDM-2/p53 Biochemical Assay Reagents Drug Intermediate	Others
3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13 .

HY-151106

FTO-IN-8	Fat Mass and Obesity-associated Protein (FTO)	Cancer
FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC₅₀ value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity .

HY-122232

SW083688	Autophagy p62	Cancer
SW083688 is a selective TAOK2 inhibitor with an IC₅₀ of 1.3 μM. SW083688 increases the abundance of p62 protein, inhibits autophagosome maturation, and blocks Autophagic flux. SW083688 is applicable for the research of non-small cell lung cancer and pancreatic cancer .

HY-19551

Apogossypolone ApoG2	Bcl-2 Family Apoptosis Autophagy Fungal ROS Kinase	Infection Cancer
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with K_i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X_L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy . Apogossypolone also has antifungal activity .

HY-112292A

GW806742X hydrochloride 20+ Cited Publications	Mixed Lineage Kinase VEGFR	Cancer
GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC₅₀=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by *cAMP-dependent protein* kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m** of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia .

HY-146302

*14-3-3η Protein inhibitor* 1** 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-178837

Z56	Ras ADC Payload	Cancer
Z56 is a Ras protein inhibitor. Z56 can be used for the research of cancer, such as pancreatic cancer .

HY-13486

TAU-IN-1	Tau Protein	Neurological Disease
TAU-IN-1 (compound 051) is a TAU protein inhibitor with an EC₅₀ value of 325 nM. TAU-IN-1 can be used in the study of neurodegenerative diseases .

HY-175840

TAU-IN-5	Tau Protein	Neurological Disease
TAU-IN-5 (compound 13) is a TAU protein inhibitor with an EC50 of 0.81 μM. TAU-IN-5 inhibits the formation of tau (2N4R isoform) oligomers and reduces the formation of tau dimers. TAU-IN-5 can be used in the study of Alzheimer's disease (AD) and Parkinson's disease (PD) .

HY-149734

MA220607	Bacterial	Infection
MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections .

HY-Y0038

2-Bromo-6-methoxynaphthalene	Trk Receptor	Cancer
2-Bromo-6-methoxynaphthalene is an active intermediate in the production of anti-inflammatory agents like Naproxen and Nabumetone by Heck reaction. 2-Bromo-6-methoxynaphthalene has potential anti-inflammatory properties and *Tyrosine-protein* inhibitor properties. 2-Bromo-6-methoxynaphthalene can be used for the research of cancer .

HY-147031

*JAMM protein inhibitor* 2**	Deubiquitinase	Cancer
JAMM protein inhibitor 2 (compound 180) is a potent JAMM protease inhibitor with IC₅₀s of 10 μM, 46 μM and 89 μM for thrombin, Rpn11 and MMP2, respectively. JAMM protein inhibitor 2 can be used for researching anticancer

HY-17660

G923-0271	DNA/RNA Synthesis	Neurological Disease
G923-0271 is a TDP-43 protein inhibitor. G923-0271 can be used for the research of neurological disease, such as Alzheimer's Disease .

HY-138562

HIV-1 Nef-IN-1	HIV	Infection
HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a K_d of 6.7 μM .

HY-P2477

*Human PD-L1 inhibitor* IV**	PD-1/PD-L1	Inflammation/Immunology
Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a K_d value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1 .

Cat. No.	Product Name	Type

HY-D0823

CY3-SE 1 Publications Verification Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester	Fluorescent Dyes
Cy3-SE (Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester) is a sulfonated cyanine dye-derived fluorescent labeling reagent with λ_ex of about 515 nm and λ_em of about 568 nm. Cy3-SE can interact with the π-π stacking of biomolecules (e.g., nucleoside monophosphates, proteins), inhibiting the photoisomerization process and increasing the fluorescence quantum yield and lifetime .

Cat. No.	Product Name	Target	Research Area

HY-120231

Z-VRPR-FMK	MALT1 NF-κB MMP	Cancer
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

HY-P1407

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA	MALT1 NF-κB MMP	Cancer
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

HY-P1380A

Difopein TFA	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein TFA is a 14-3-3 protein inhibitor. Difopein TFA acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein TFA serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein TFA is applicable to glioma-related research .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by *cAMP-dependent protein* kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m** of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia .

HY-P2477

*Human PD-L1 inhibitor* IV**	PD-1/PD-L1	Inflammation/Immunology
Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a K_d value of 1.38 μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1 .

HY-P10948

CS-VIP 8	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia .

HY-P4544

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone	MALT1 NF-κB MMP	Cancer
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

HY-P1597A

Malantide TFA	PKA PKC	Cancer
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by *cAMP-dependent protein* kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a K_m** of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P1380

Difopein	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein is a 14-3-3 protein inhibitor. Difopein acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein is applicable to glioma-related research .

Cat. No.	Product Name

HY-K0017

*Kinase Inhibitor* Cocktail** 2 Publications Verification
MCE Kinase Inhibitor Cocktail controls the biological activity of kinases. This inhibitor is primarily used for Biochemicals applications.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0011

*Protease Inhibitor* Cocktail, mini-Tablet (EDTA-Free)** 250+ Cited Publications
MCE Protease Inhibitor Cocktail, mini-Tablet (EDTA-Free) is a blend of 5 pan-protease inhibitors for protection of protein integrity. The 25 pcs is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0023

*Phosphatase Inhibitor* Cocktail Ⅲ (100× in DMSO)** 240+ Cited Publications
Phosphatase Inhibitor Cocktail Ⅲ (100× in DMSO) is a mixture of multiple phosphatase inhibitors that effectively inhibit serine/threonine phosphatases and alkaline phosphatases, and is used to preserve the phosphorylation status of proteins.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0016

Kinase Assay Buffer 3 Publications Verification
MCE Kinase Assay Buffer can be used for assaying kinase protein. The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0022

*Phosphatase Inhibitor* Cocktail Ⅱ (100× in ddH₂O)** 455+ Cited Publications
Phosphatase Inhibitor Cocktail Ⅱ (100× in ddH₂O) is a blend of 5 phosphatase inhibitors that can broadly inhibit acid phosphatases, alkaline phosphatases, and protein tyrosine phosphatases (PTPs).The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0013

*Protease and Phosphatase Inhibitor* Cocktail (EDTA-Free, 10× in ddH₂O)** 140+ Cited Publications
MCE Protease and Phosphatase Inhibitor Cocktail (EDTA-Free, 10× in ddH₂O) protects protein from degradation by endogenous proteases released during protein extraction and purification.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0021

*Phosphatase Inhibitor* Cocktail I (100× in DMSO)** 670+ Cited Publications
Phosphatase Inhibitor Cocktail I (100× in DMSO) is a blend of 2 phosphatase inhibitors that can effectively inhibit alkaline phosphatases and serine/threonine phosphatases. It is used to maintain the phosphorylation status of proteins.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0012

*Protease Inhibitor* Cocktail, Bacteria (EDTA-Free, 100× in DMSO)** 10+ Cited Publications
MCE Protease Inhibitor Cocktail, Bacteria (EDTA-Free, 100× in DMSO) protects proteins from degradation by endogenous proteases released during protein extraction and purification.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0010

*Protease Inhibitor* Cocktail (EDTA-Free, 100× in DMSO)** Maximum Cited Publications 1922 Publications Verification
MCE Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO) is a blend of 6 pan-protease inhibitors for protection of protein integrity.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99648

Gosuranemab BMS-986168; IPN007; BIIB092	Tau Protein	Neurological Disease
Gosuranemab (BMS-986168; IPN007; BIIB092) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease .

HY-P99648A

Gosuranemab (powder) BMS-986168 (powder); IPN007 (powder); BIIB092 (powder)	Tau Protein	Neurological Disease
Gosuranemab (BMS-986168; IPN007; BIIB092) (powder) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab (powder) neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab (powder) can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1192

Estradiol benzoate 15+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-111557

YM-254890 15+ Cited Publications	Cardiovascular Disease Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	P2Y Receptor
YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y₁ signal transduction pathway, with an IC₅₀ value below 0.6 μM .

HY-128483

Fusaric acid	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-W010041

Scyllo-Inositol	Natural Products Endogenous metabolite Source Classification	α-synuclein Amyloid-β
Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-N11902

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one	Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	SARS-CoV
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor can be isolated from Curcuma kwangsiensis. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one exhibits excellent antiviral activity against HCoV-OC43 and SARS-CoV-2,with EC₅₀ values of 0.16 μM and 0.17 μM, respectively .

HY-N7763

Casuarictin	Lythraceae Trapa natans L. Phenols Polyphenols Plants Source Classification	Glycosidase
Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC₅₀ of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research .

HY-N6777R

Penicillic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Caspase Bacterial Apoptosis Antibiotic
Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-W010041R

Scyllo-Inositol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards α-synuclein Amyloid-β
Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-128483R

Fusaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor Reference Standards
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-150033

Sorgoleone	Quinones Structural Classification Sorghum bicolor (Linn.) Moench Gramineae Benzene Quinones Plants Source Classification	Photosystem II Herbicide
Sorgoleone is a photosystem II inhibitor found in sorghum. Sorgoleone binds to the Q_B niche of the D1 protein, inhibits photosynthetic electron transport, and does not affect photosystem I reactions. Sorgoleone reduces radicle elongation and stunts growth. Sorgoleone inhibits CO₂-dependent oxygen evolution, photosynthetic O₂ evolution, and mitochondrial respiration. Sorgoleone can be used as a herbicide .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70048

	*PIN/DYNLL1 Protein, Human (His)* rHuDynein light chain 1, cytoplasmic/DYNLL1, His; Dynein Light Chain 1 Cytoplasmic; 8 kDa Dynein Light Chain; DLC8; Dynein Light Chain LC8-Type 1; Protein Inhibitor of Neuronal Nitric Oxide Synthase; PIN; DYNLL1; DLC1; DNCL1; DNCLC1; HDLC1	Human	E. coli
	PIN/DYNLL1 acts as a non-catalytic accessory component in the cytoplasmic dynein 1 complex, connecting dynein to cargos and adapter proteins for dynein modulation. It functions as a motor for retrograde vesicle movement along microtubules, potentially influencing cytoskeletal structure. PIN/DYNLL1 enhances ESR1 transactivation and aids ESR1 nuclear localization. PIN/DYNLL1 Protein, Human (His) is the recombinant human-derived PIN/DYNLL1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-10466S

Daclatasvir-d6
Daclatasvir-d₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

HY-10466S2

Daclatasvir-d16
Daclatasvir-d₁₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

HY-10466S1

Daclatasvir-13C2,d6

Daclatasvir- ¹³C2,d₆ (BMS-790052- ¹³C2,d₆) is ¹³C and deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

HY-W707693

Scyllo-Inositol-d6

Scyllo-Inositol-d₆ is the deuterium labeled Scyllo-Inositol (HY-W010041). Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (3) IP (1) WB (3) FC (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82730

	PIAS1/2 Antibody (YA2475) PIAS1; PIAS2; PIAS3; Protein inhibitor of activated STAT protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PIAS1/2 Antibody (YA2475) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIAS1/2.

HY-P83100

	ID1 Antibody (YA2845) DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; ID1; BHLHB24; ID	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	ID1 Antibody (YA2845) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ID1.

HY-P82472

	PIAS1 Antibody (YA2217) PIAS1; DDXBP1; E3 SUMO-protein ligase PIAS1; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PIAS1 Antibody (YA2217) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIAS1.