2. Tz-Thalidomide

Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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Tz-Thalidomide Chemical Structure

Tz-Thalidomide Chemical Structure

CAS No. : 2087490-42-2

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 201 In-stock
Solid
5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 520 In-stock
50 mg USD 830 In-stock
100 mg USD 1330 In-stock
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Tz-Thalidomide Related Antibodies

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Description

Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].

IC50 & Target

46.25 μM (BRD4-1), 62.55 μM (BRD4-2)[1]
Molecular Weight

571.58

Formula

C29H29N7O6
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

O=C(CCCCCOC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1)NCC(C=C4)=CC=C4C5=NN=C(C)N=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (87.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7495 mL 8.7477 mL 17.4954 mL
5 mM 0.3499 mL 1.7495 mL 3.4991 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7495 mL 8.7477 mL 17.4954 mL 43.7384 mL
5 mM 0.3499 mL 1.7495 mL 3.4991 mL 8.7477 mL
10 mM 0.1750 mL 0.8748 mL 1.7495 mL 4.3738 mL
15 mM 0.1166 mL 0.5832 mL 1.1664 mL 2.9159 mL
20 mM 0.0875 mL 0.4374 mL 0.8748 mL 2.1869 mL
25 mM 0.0700 mL 0.3499 mL 0.6998 mL 1.7495 mL
30 mM 0.0583 mL 0.2916 mL 0.5832 mL 1.4579 mL
40 mM 0.0437 mL 0.2187 mL 0.4374 mL 1.0935 mL
50 mM 0.0350 mL 0.1750 mL 0.3499 mL 0.8748 mL
60 mM 0.0292 mL 0.1458 mL 0.2916 mL 0.7290 mL
80 mM 0.0219 mL 0.1093 mL 0.2187 mL 0.5467 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tz-Thalidomide2087490-42-2Inhibitorinhibitorinhibit

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