PROTAC MAGL degrader-1
PROTAC MAGL degrader-1 is an orally active PROTAC agent that simultaneously targets monoacylglycerol lipase (MAGL) and E3 ubiquitin ligase MDM2. PROTAC MAGL degrader-1 degrades MAGL and inhibits the binding of MDM2 to p53. PROTAC MAGL degrader-1 can partially penetrate the blood-brain barrier (BBB). PROTAC MAGL degrader-1 induces glioblastoma stem cells (GSCs) apoptosis.
(Pink: MAGL ligand (HY-15249); Blue: MDM2 ligand (HY-128837); Black: linker).
For research use only. We do not sell to patients.
- Formula: C60H58Cl2N6O14
- Molecular Weight:1158.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
Chemical Information
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Molecular Weight 1158.04
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Formula C60H58Cl2N6O14
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SMILES
ClC1=CC=C([C@@]2([H])[C@@]([H])(C3=CC=C(Cl)C=C3)N(C(N4CC(N(CC(OCCOC5=CC=C(C(C6CCN(C(OC7=CC=C([N+]([O-])=O)C=C7)=O)CC6)(O)C8=CC=C(OCO9)C9=C8)C=C5)=O)CC4)=O)=O)C(C%10=CC=C(OC)C=C%10OC(C)C)=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC MAGL degrader-1 Related Classifications
HY-173369 Related Classifications
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