2. Immunology/Inflammation
  3. FAP
  4. DOTAGA.(SA.FAPi)2 analogue TFA

DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi).

For research use only. We do not sell to patients.

DOTAGA.(SA.FAPi)2 analogue TFA

DOTAGA.(SA.FAPi)2 analogue TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

DOTAGA.(SA.FAPi)2 analogue TFA Related Antibodies

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Description

DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi)[1].

Molecular Weight

1679.61

Formula

C75H89F7N18O19
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C(F)(F)F)=O.O=C(O)CN1CCN(C(CCC(NCCNC(C2=O)=C(NCCCCOC3=CC4=C(N=CC=C4C(NCC(N5[C@H](C#N)CC(C5)(F)F)=O)=O)C=C3)C2=O)=O)C(O)=O)CCN(CCN(CC1)CCNCCNC(C6=O)=C(NCCCCOC7=CC8=C(N=CC=C8C(NCC(N9[C@H](C#N)CC(C9)(F)F)=O)=O)C=C7)C6=O)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (59.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5954 mL 2.9769 mL 5.9538 mL
5 mM 0.1191 mL 0.5954 mL 1.1908 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5954 mL 2.9769 mL 5.9538 mL 14.8844 mL
5 mM 0.1191 mL 0.5954 mL 1.1908 mL 2.9769 mL
10 mM 0.0595 mL 0.2977 mL 0.5954 mL 1.4884 mL
15 mM 0.0397 mL 0.1985 mL 0.3969 mL 0.9923 mL
20 mM 0.0298 mL 0.1488 mL 0.2977 mL 0.7442 mL
25 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5954 mL
30 mM 0.0198 mL 0.0992 mL 0.1985 mL 0.4961 mL
40 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3721 mL
50 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2977 mL
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DOTAGA.(SA.FAPi)2 analogue TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTAGA.(SA.FAPi)2 analogueFAPFibroblast activation proteinDOTAGA.(SA.FAPi)2 TFA analogueFAP inhibitorInhibitorinhibitorinhibit

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