DOTAGA.(SA.FAPi)2 analogue TFA
Based on 1 Customer Validation
DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi).
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- Pureté : 99.38%
- Formule: C75H89F7N18O19
- Masse moléculaire:1679.61
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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Appearance Solid
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Masse moléculaire 1679.61
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Formule C75H89F7N18O19
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Color Light yellow to yellow
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SMILES
OC(C(F)(F)F)=O.O=C(O)CN1CCN(C(CCC(NCCNC(C2=O)=C(NCCCCOC3=CC4=C(N=CC=C4C(NCC(N5[C@H](C#N)CC(C5)(F)F)=O)=O)C=C3)C2=O)=O)C(O)=O)CCN(CCN(CC1)CCNCCNC(C6=O)=C(NCCCCOC7=CC8=C(N=CC=C8C(NCC(N9[C@H](C#N)CC(C9)(F)F)=O)=O)C=C7)C6=O)CC(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (59.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tilman Läppchen, et al. Tailoring Fibroblast-Activation Protein Targeting for Theranostics: A Comparative Preclinical Evaluation of the 68Ga- and 177Lu-Labeled Monomeric and Dimeric Fibroblast-Activation Protein Inhibitors DOTA.SA.FAPi and DOTAGA.(SA.FAPi)2. Molecules. 2024 Jun 28;29(13):3093. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5954 mL | 2.9769 mL | 5.9538 mL | 14.8844 mL |
| 5 mM | 0.1191 mL | 0.5954 mL | 1.1908 mL | 2.9769 mL | |
| 10 mM | 0.0595 mL | 0.2977 mL | 0.5954 mL | 1.4884 mL | |
| 15 mM | 0.0397 mL | 0.1985 mL | 0.3969 mL | 0.9923 mL | |
| 20 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7442 mL | |
| 25 mM | 0.0238 mL | 0.1191 mL | 0.2382 mL | 0.5954 mL | |
| 30 mM | 0.0198 mL | 0.0992 mL | 0.1985 mL | 0.4961 mL | |
| 40 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3721 mL | |
| 50 mM | 0.0119 mL | 0.0595 mL | 0.1191 mL | 0.2977 mL |
DOTAGA.(SA.FAPi)2 analogue TFA Related Classifications
HY-164364B Related Classifications
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