2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Anticancer agent 198

Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells.

For research use only. We do not sell to patients.

Anticancer agent 198

Anticancer agent 198 Chemical Structure

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Anticancer agent 198 Related Antibodies

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Description

Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 18b
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 38442524]
HEK-293T IC50
1.1 μM
Compound: 18b
Antiproliferative activity against HEK293T cells incubated for 48 hrs by MTT assay
Antiproliferative activity against HEK293T cells incubated for 48 hrs by MTT assay
[PMID: 38442524]
HeLa IC50
> 10 μM
Compound: 18b
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
[PMID: 38442524]
K562 IC50
0.05 μM
Compound: 18b
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
[PMID: 38442524]
PC-3 IC50
> 10 μM
Compound: 18b
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by MTT assay
[PMID: 38442524]
In Vitro

Anticancer agent 198 significantly inhibits the survival of PC3-WRN cells, with IC20 of 0.12 μM and 0.98 μM between PC3-WRN (OE) cells and PC3 cells, respectively[1].
Anticancer agent 198 (5 μM) against several cancers The IC50s of the cell lines are >10 μM (PC3 cells), 0.05 μM (K562 cells), and 1.1 μM (293T cells)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 198 Related Antibodies

Cell Viability Assay[1]

Cell Line: PC3, K562, A549, HeLa, 293T cells
Concentration: 5 μM
Incubation Time:
Result: Showed inhibition rates of 62.7% (PC3), 65.57% (K562), 53.27% (HeLa), 51.27% (A549), 63.67% (293T), respectively.
Molecular Weight

451.47

Formula

C25H23F2N3O3
SMILES

COC1=CC=CC(C(F)(C2=NC3=CC=CC=C3C(N(C4=CC(OC)=C(C=C4)OC)C)=N2)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 198 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 198Anticancer agent198Anticancer agent-198DNA/RNA SynthesisAnticancer activityQuinzoline derivativesStructure designSynthesisWRN HelicaseInhibitorinhibitorinhibit

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