RSV fusion protein IN-1 

RSV fusion protein IN-1 is an orally active RSV pre-fusion F protein inhibitor with an IC₅₀ of 0.10 nM against RSV. RSV fusion protein IN-1 forms stable hydrogen bonds and π-π stacking interactions with pre-fusion F protein to block viral fusion and entry. RSV fusion protein IN-1 suppresses RSV F protein expression in epithelial cells. RSV fusion protein IN-1 reduces viral burden in the lungs of RSV-infected murine models.RSV fusion protein IN-1 can be used for the research of respiratory syncytial virus (RSV) infection^[1].

RSV fusion protein IN-1 (Compound 21) potently inhibits RSV replication in HEp-2 cells with an IC₅₀ of 0.10 nM, a TC₅₀ of 7.8 μM for HEp-2 cells and a selectivity index of 78,000^[1].
RSV fusion protein IN-1 (3.75-15 nM; 48 h) dose-dependently suppresses RSV F protein expression in HEp-2 cells, with 98% reduction at 15 nM after 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RSV fusion protein IN-1 (Compound 21) (10 mg/kg; i.p. or 50 mg/kg; p.o.; single administration) reduces RSV-induced lung injury and viral burden in BALB/c mice, with 10 mg/kg intraperitoneal administration producing a more potent effect than 50 mg/kg oral administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

551.42

C₂₄H₂₂BrF₃N₄OS

NCC1=CC2=C(N(C(CN(C3=CC=CC=C3)C(C4=C(C=CS4)Br)=O)=N2)CCCC(F)(F)F)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zaman MK, et al. Design, synthesis and pharmacological evaluation of phenylthiophene-2-carboxamide-based RSV fusion protein inhibitors. Bioorg Chem. Published online February 26, 2026.  [Content Brief]