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Cat. No.: HY-182030

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RSV fusion protein IN-1

RSV fusion protein IN-1 is an orally active RSV pre-fusion F protein inhibitor with an IC₅₀ of 0.10 nM against RSV. RSV fusion protein IN-1 forms stable hydrogen bonds and π-π stacking interactions with pre-fusion F protein to block viral fusion and entry. RSV fusion protein IN-1 suppresses RSV F protein expression in epithelial cells. RSV fusion protein IN-1 reduces viral burden in the lungs of RSV-infected murine models.RSV fusion protein IN-1 can be used for the research of respiratory syncytial virus (RSV) infection.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₂BrF₃N₄OS
Molecular Weight:551.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RSV fusion protein IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

RSV fusion protein IN-1 (Compound 21) potently inhibits RSV replication in HEp-2 cells with an IC₅₀ of 0.10 nM, a TC₅₀ of 7.8 μM for HEp-2 cells and a selectivity index of 78,000^[1].
RSV fusion protein IN-1 (3.75-15 nM; 48 h) dose-dependently suppresses RSV F protein expression in HEp-2 cells, with 98% reduction at 15 nM after 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HEp-2 cells
Concentration:

3.75, 7.5, 15 nM
Incubation Time:

48 h
Result:

Reduced RSV F protein signal intensity by 69% at 3.75 nM compared to the virus control group.
Reduced RSV F protein signal intensity by 92% at 7.5 nM compared to the virus control group.
Reduced RSV F protein signal intensity by 98% at 15 nM compared to the virus control group.

In Vivo

RSV fusion protein IN-1 (Compound 21) (10 mg/kg; i.p. or 50 mg/kg; p.o.; single administration) reduces RSV-induced lung injury and viral burden in BALB/c mice, with 10 mg/kg intraperitoneal administration producing a more potent effect than 50 mg/kg oral administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (4-week-old female; intranasally infected with RSV Long strain)^[1]
Dosage:

10 mg/kg (i.p.); 50 mg/kg (p.o.)
Administration:

i.p.; single administration; p.o.; single administration
Result:

Reduced lung index significantly compared to the RSV-infected control group, and decreased RSV-F gene copy number in lung tissue significantly.
Showed greater efficacy via intraperitoneal administration than oral dosing.

Chemical Information

Molecular Weight 551.42
Formula C₂₄H₂₂BrF₃N₄OS
SMILES

NCC1=CC2=C(N(C(CN(C3=CC=CC=C3)C(C4=C(C=CS4)Br)=O)=N2)CCCC(F)(F)F)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zaman MK, et al. Design, synthesis and pharmacological evaluation of phenylthiophene-2-carboxamide-based RSV fusion protein inhibitors. Bioorg Chem. Published online February 26, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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