Mcl-1-IN-21
Mcl-1-IN-21 is a selective Mcl-1 protein inhibitor. Mcl-1-IN-21 can induce apoptosis, elevate intracellular ROS, reduce mitochondrial membrane potential, exert cytotoxicity against human cervical cancer cells, and inhibit tumor growth in a human cervical cancer xenograft mouse model. Mcl-1-IN-21 can be used for the research of cervical cancer.
For research use only. We do not sell to patients.
- Formula: C39H48BrF3N3O7PS
- Molecular Weight:870.75
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Mcl-1 |
Mcl-1-IN-21 (compound 9k) (48 h) exhibits potent cytotoxicity against Hela cells (IC50 = 9.55 μM) and moderate activity against MGC-803, HepG2, and LO-2 cells[1].
Mcl-1-IN-21 (5-20 μM; 24 h) induces chromatin condensation in Hela cells at 10 μM and 20 μM after 24 h[1].
Mcl-1-IN-21 (5-20 μM; 24 h) can induce dose-dependent accumulation of ROS in Hela cells after 24 h and reduce mitochondrial membrane potential[1].
Mcl-1-IN-21 (5-20 μM; 24 h) induces concentration-dependent apoptosis in Hela cells after 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Hela
-
Concentration:5 μM, 10 μM, 20 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis in 11.3%, 17.4%, and 24.4% of Hela cells at 5 μM, 10 μM, and 20 μM, respectively, compared to 6.7% in the control.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude (five-week-old, male) injected with Hela cells[1]
-
Dosage:5 mg/kg; 10 mg/kg
-
Administration:i.p.; once every other day; 21 days
-
Result:Induced dose-dependent tumor growth inhibition with tumor growth inhibition rates of 17% (5 mg/kg) and 21% (10 mg/kg); did not cause obvious body weight loss or adverse effects.
Chemical Information
-
Molecular Weight 870.75
-
Formula C39H48BrF3N3O7PS
-
SMILES
O=S(N1C(CCCC(OC2=CC=C(C(P(OCC)(OCC)=O)NC3=CC(Br)=CC=C3)C=C2)=O)C4C5C(CCCN5CCC4)C1)(C6=CC=C(C(F)(F)F)C=C6)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz