Mcl-1-IN-21
Mcl-1-IN-21 is a selective Mcl-1 protein inhibitor. Mcl-1-IN-21 can induce apoptosis, elevate intracellular ROS, reduce mitochondrial membrane potential, exert cytotoxicity against human cervical cancer cells, and inhibit tumor growth in a human cervical cancer xenograft mouse model. Mcl-1-IN-21 can be used for the research of cervical cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C39H48BrF3N3O7PS
- 分子量:870.75
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Mcl-1 |
Mcl-1-IN-21 (compound 9k) (48 h) exhibits potent cytotoxicity against Hela cells (IC50 = 9.55 μM) and moderate activity against MGC-803, HepG2, and LO-2 cells[1].
Mcl-1-IN-21 (5-20 μM; 24 h) induces chromatin condensation in Hela cells at 10 μM and 20 μM after 24 h[1].
Mcl-1-IN-21 (5-20 μM; 24 h) can induce dose-dependent accumulation of ROS in Hela cells after 24 h and reduce mitochondrial membrane potential[1].
Mcl-1-IN-21 (5-20 μM; 24 h) induces concentration-dependent apoptosis in Hela cells after 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:24 h
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Result:Induced apoptosis in 11.3%, 17.4%, and 24.4% of Hela cells at 5 μM, 10 μM, and 20 μM, respectively, compared to 6.7% in the control.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (five-week-old, male) injected with Hela cells[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:i.p.; once every other day; 21 days
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Result:Induced dose-dependent tumor growth inhibition with tumor growth inhibition rates of 17% (5 mg/kg) and 21% (10 mg/kg); did not cause obvious body weight loss or adverse effects.
化学情報
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分子量 870.75
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分子式 C39H48BrF3N3O7PS
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SMILES
O=S(N1C(CCCC(OC2=CC=C(C(P(OCC)(OCC)=O)NC3=CC(Br)=CC=C3)C=C2)=O)C4C5C(CCCN5CCC4)C1)(C6=CC=C(C(F)(F)F)C=C6)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Mcl-1-IN-21 関連分類
HY-181054 関連分類
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