2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS)
  4. Mcl-1-IN-21

Mcl-1-IN-21 is a selective Mcl-1 protein inhibitor. Mcl-1-IN-21 can induce apoptosis, elevate intracellular ROS, reduce mitochondrial membrane potential, exert cytotoxicity against human cervical cancer cells, and inhibit tumor growth in a human cervical cancer xenograft mouse model. Mcl-1-IN-21 can be used for the research of cervical cancer.

For research use only. We do not sell to patients.

Mcl-1-IN-21

Mcl-1-IN-21 Chemical Structure

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Mcl-1-IN-21 Related Antibodies

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Description

Mcl-1-IN-21 is a selective Mcl-1 protein inhibitor. Mcl-1-IN-21 can induce apoptosis, elevate intracellular ROS, reduce mitochondrial membrane potential, exert cytotoxicity against human cervical cancer cells, and inhibit tumor growth in a human cervical cancer xenograft mouse model. Mcl-1-IN-21 can be used for the research of cervical cancer[1].

IC50 & Target[1]

Mcl-1

 

In Vitro

Mcl-1-IN-21 (compound 9k) (48 h) exhibits potent cytotoxicity against Hela cells (IC50 = 9.55 μM) and moderate activity against MGC-803, HepG2, and LO-2 cells[1].
Mcl-1-IN-21 (5-20 μM; 24 h) induces chromatin condensation in Hela cells at 10 μM and 20 μM after 24 h[1].
Mcl-1-IN-21 (5-20 μM; 24 h) can induce dose-dependent accumulation of ROS in Hela cells after 24 h and reduce mitochondrial membrane potential[1].
Mcl-1-IN-21 (5-20 μM; 24 h) induces concentration-dependent apoptosis in Hela cells after 24 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mcl-1-IN-21 Related Antibodies

Apoptosis Analysis[1]

Cell Line: Hela
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 h
Result: Induced apoptosis in 11.3%, 17.4%, and 24.4% of Hela cells at 5 μM, 10 μM, and 20 μM, respectively, compared to 6.7% in the control.
In Vivo

Mcl-1-IN-21 (compound 9k) (5-10 mg/kg; i.p.; once every other day; 21 days) exhibits dose-dependent antitumor activity in Hela xenograft mice with 17% and 21% tumor growth inhibition at 5 mg/kg and 10 mg/kg, respectively, and no obvious toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (five-week-old, male) injected with Hela cells[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.; once every other day; 21 days
Result: Induced dose-dependent tumor growth inhibition with tumor growth inhibition rates of 17% (5 mg/kg) and 21% (10 mg/kg); did not cause obvious body weight loss or adverse effects.
Molecular Weight

870.75

Formula

C39H48BrF3N3O7PS
SMILES

O=S(N1C(CCCC(OC2=CC=C(C(P(OCC)(OCC)=O)NC3=CC(Br)=CC=C3)C=C2)=O)C4C5C(CCCN5CCC4)C1)(C6=CC=C(C(F)(F)F)C=C6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mcl-1-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mcl-1-IN-21Bcl-2 FamilyApoptosisReactive Oxygen Species (ROS)HepG2 cellshuman cervical cancer cellshuman cervical cancer xenograft mouse modelapoptosisMcl-1 proteinintracellular ROShuman cervical cancermitochondrial membrane potentialMGC-803 cellsHela cellsInhibitorinhibitorinhibit

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