Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.
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- Formule: C31H49FN10O6·xC2HF3O2
- Masse moléculaire:676.78 (free base)
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (Compound Z-VRPR-FMK) (50 μM, 24 h) TFA can effectively reduce the level of c-REL in the nucleus of HBL-1 cells and inhibit the signal transduction of NF-κB[2].
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (50 μM, 48 h) TFA can inhibit the proliferation of ABC-DLBCL cell lines HBL-1, TMD8, OCI-Ly3 and OCI-Ly10[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 676.78 (free base)
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Formule C31H49FN10O6·xC2HF3O2
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Color White to off-white
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
H2O : 1 mg/mL (Need ultrasonic and warming)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. [Content Brief]
[2]. Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA Related Classifications
HY-P1407 Related Classifications
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